NL-OMON53691尚未招募不适用
The Clock thickens: Morning or evening training for the treatment of NAFLD? - TikTac study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 40
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- Age >= 45 years and <= 75
- •- Obese (BMI > 27 kg/m2)
- •- Males and postmenopausal females
- •- Caucasian
- •- Hepatic steatosis defined as increased hyperechogenicity of the liver on
- •abdominal ultrasound, CAP score on Fibroscan > 280, and/or histological signs
- •of steatosis
- •- Sedentary lifestyle (maximum of 20*minutes of moderate-to-vigorous physical
- •activity per day on less than three days per week)
- •- Written informed consent
排除标准
- •- Exclusion criteria for MRI (claustrophobia, pacemaker, metal implants, etc.)
- •- Any other liver disease than NAFLD/NASH
- •- Present excessive alcohol use defined as > 2 units/day
- •- Recent use (< 3 months) of antibiotics
- •- Recent changes in dosages of regular medication (< 3 months)
- •- Recent (< 3 months) weight change (>5%)
- •- Recent (< 3 months) substantial diet changes
- •- Cardiovascular co-morbidity defined as heart failure, coronary insufficiency
- •and hypertension in past history
- •- Comorbidity that contraindicates exercise training and exercise testing or
- •that affects exercise response and exercise capacity
- •- Ongoing or recent use of glucocorticoids, oral/transdermal hormonal
- •substitution, paclitaxel, theofyllin, amiodarone, myelosuppresive agents
- •- A psychiatric, addictive or any other disorder that compromises the subjects
- •ability to understand the study content and to give written informed consent
- •for participation in the study
- •- Working night or alternating shifts, known sleeping disorders such as
- •narcolepsy or insomnia
研究者
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