Brain Structures in Speech Motor Memory Consolidation
Trial Snapshot
- Phase
- Not Applicable
- Status
- Terminated
- Sponsor
- Yale University
- Enrollment
- 160
- Locations
- 1
- Primary Endpoint
- Motor Learning
Study Overview
Brief Summary
These studies test the hypothesis that sensory areas of the brain participate in the consolidation of speech motor memory by using transcranial magnetic stimulation to suppress activity in somatosensory and auditory cortex following adaptation in order to block retention of learning.
Detailed Description
Subjects will train using either altered somatosensory feedback or altered auditory feedback (different groups of subjects). Immediately following adaptation, continuous theta burst magnetic stimulation (cTBS) will be applied to either auditory or somatosensory or motor cortex with the goal of blocking consolidation of motor memory. The logic of applying cTBS to both sensory areas is to test the hypothesis that both areas are involved in motor memory consolidation. Subjects leave the laboratory following cTBS and return 24 hours later to assess retention of learning. Learning is assessed as percentage change in speech sounds or movements relative to baseline. Retention is measured on a 0 to 100 scale relative to the end of learning.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 21 Years to 40 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •right handed adults
- •no known physical or neurological abnormalities
Exclusion Criteria
- •patients with:
- •cardiac pacemaker
- •surgical clips or values on the heart
- •metal or metallic fragments in any part of the body
- •pregnancy
- •claustrophobia
- •a personal or family history of epilepsy
- •currently taking antipsychotic drugs
- •currently taking antidepressant drugs
- •currently taking antianxiety drugs
- •history of concussion.
Arms & Interventions
Adaptation to Altered Sensory Feedback + cTBS to A1
Adaptation to Altered Sensory Feedback + cTBS to A1
Intervention: cTBS (Other)
Adaptation to Altered Sensory Feedback + cTBS to M1
Adaptation to Altered Sensory Feedback + cTBS to M1
Intervention: Adaptation (Behavioral)
Adaptation to Altered Sensory Feedback + cTBS to S1
Adaptation to Altered Sensory Feedback + cTBS to S1
Intervention: Adaptation (Behavioral)
Adaptation to Altered Sensory Feedback + cTBS to S1
Adaptation to Altered Sensory Feedback + cTBS to S1
Intervention: cTBS (Other)
Adaptation to Altered Sensory Feedback + cTBS to A1
Adaptation to Altered Sensory Feedback + cTBS to A1
Intervention: Adaptation (Behavioral)
Adaptation to Altered Sensory Feedback + cTBS to M1
Adaptation to Altered Sensory Feedback + cTBS to M1
Intervention: cTBS (Other)
Adaptation to Altered Sensory Feedback + Sham cTBS
Adaptation to Altered Sensory Feedback + Sham cTBS
Intervention: Adaptation (Behavioral)
Adaptation to Altered Sensory Feedback + Sham cTBS
Adaptation to Altered Sensory Feedback + Sham cTBS
Intervention: cTBS (Other)
Outcomes
Primary Outcomes
Motor Learning
Time Frame: Performance as measured at the end of learning (30 minute session)
Learning is assessed as percentage change in speech sounds (speech formant frequencies) or movements (movement curvature) relative to baseline.
Retention of Learning
Time Frame: 24 hours after learning (re-test lasts 30 minutes)
Retention is measured on a 0 to 100 scale relative to the end of learning.
Secondary Outcomes
No secondary outcomes reported