Oscillatory Activity in Basal Ganglia Circuits During Normal and Pathological Movement
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- difference in the cortico-subcortical electrophysiological coherence value
研究概览
简要总结
The expression of hypokinetic and hyperkinetic motor symptoms is accompanied by pathological synchronous oscillations of neuronal activity in this cortico-subcortical network with a wide frequency range.
The purpose of this research is to study cortico-subcortical oscillations and their synchronization in two pathologies emblematic of hypokinetic (Parkinson's disease) and hyperkinetic (epilepsies) phenomena using a simple motor task and comparing different situations.
详细描述
In order to define the link between the characteristics of the oscillations (frequency, amplitude, phase relation) within this cortico-subcortical network and movement (normal or pathological) in humans, a simple motor task of gripping/pulling a lever has been designed.
The local field potentials (LFPs) will be collected during the same motor task in :
i) patients with Parkinson's disease, using a high-resolution electroencephalogram (EEG) and the PERCEPT(TM) system (Medtronic) equipped with a "sensing" function for deep LFP recordings and in EEG-HR (for high resolution) for cortical recordings
ii) patients with focal drug-resistant epilepsy, during a pre-surgical assessment by stereo-electro-encephalography (SEEG). The SEEG allows the recording of both the cortex and the subcortical regions in a concomitant manner, and a direct correlation can be studied.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or Female
- •Between 18 and 75 years of age
- •With Parkinson's disease and already operated with implantation of electrodes in the Subthalamic nucleus connected to a PERCEPT (TM) device.
- •Giving free, informed, written consent signed by the participant and the investigator Or
- •With drug-resistant epilepsy and benefiting from a phase II pre-surgical assessment with intracerebral electrophysiological exploration by stereo-EEG
- •With at least one electrode exploring the basal ganglia or the thalamus.
- •Able to perform the simple motor task
- •Affiliated or beneficiary of a social security scheme;
- •Giving free, informed, written consent signed by the participant and the investigator
排除标准
- •Be incapable of giving consent personally
- •Be subject to a legal protection measure or be placed under judicial protection;
- •Being pregnant or breastfeeding
- •Present a serious and/or decompensated somatic or psychiatric illness
结局指标
主要结局
difference in the cortico-subcortical electrophysiological coherence value
时间窗: Day 1
difference in the cortico-subcortical electrophysiological coherence value between normal movement (control condition) and hypo- or hyperkinetic pathological movement
次要结局
未报告次要终点