Optical Coherence Tomography of the Airway for Lung Cancer or Lung Disease
- Conditions
- Lung CancerPrecancerous ConditionMalignant MesotheliomaMetastatic CancerNonmalignant Neoplasm
- Registration Number
- NCT00733252
- Lead Sponsor
- Case Comprehensive Cancer Center
- Brief Summary
RATIONALE: Diagnostic procedures, such as optical coherence tomography, may help find and diagnose lung cancer or precancerous cells.
PURPOSE: This phase I trial is studying how well optical coherence tomography of the airway works in detecting abnormal cells in patients undergoing surgery for lung cancer or lung disease.
- Detailed Description
OBJECTIVES:
* Correlate optical coherence tomography images of the airway with airway histology.
* Develop an imaging technique to detect premalignant airway epithelial changes (carcinoma in situ, dysplasia) to study the transformation process as well as intervene and prevent the development of lung cancer.
OUTLINE: Bronchoscopic imaging and optical coherence tomography are performed on lung tissue samples collected during surgery. All imaged areas are marked. The marked areas are then excised and fixed in formalin for histopathologic analysis.
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Correlation of optical coherence tomography images of the airway with airway histology This study will involve discarded tissue from 10 subjects with pathology specimens over one year.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center
🇺🇸Cleveland, Ohio, United States