Effect of Commute Traffic on Vascular Function
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Change in Brachial Artery Diameter from Pre-Drive to Post-Drive
研究概览
简要总结
The investigators will assess the vascular effects of riding in a car in heavily trafficked roadways, and whether filtering the car's air reduces those effects.
详细描述
In this double-blind, crossover trial, randomized to order, recruited participants will be screened and then will accompany the study team on three typical commutes on separate days with sufficient washout (i.e., three weeks) between drives. One day this will occur with an effective filter system in the vehicle and the other two days without effective filtration; ineffective filtration is the most typical actual vehicle condition. Subjects will be unaware of the filtration conditions of the commute on that day. Each subject's experimental sessions will occur at the same time of day and will be separated by at least 21 days. The two sessions (either filtered air or traffic-derived entrained air) will be 120 minutes in duration and will encompass routes on heavily traveled roadways in the Seattle area. Before subjects begin the commute trials, they will go through the consent process and a series of screening tests. The study investigators will assess a series of measures regarding vascular function before and after each drive.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 49 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •high blood pressure,
- •diabetes,
- •high cholesterol,
- •other chronic conditions requiring ongoing medical care.
研究组 & 干预措施
Typical Commute
Participants spend two hours in automobile, on heavily trafficked roadways, without active filtration of air pollutants
Typical Commute, Filtered Air
Participants spend two hours in automobile, on heavily trafficked roadways, with active filtration of air pollutants
干预措施: Filtered Air (Other)
结局指标
主要结局
Change in Brachial Artery Diameter from Pre-Drive to Post-Drive
时间窗: 30 minutes before 120 minute driving session; 30 minutes post driving session
Ultrasound assessment of brachial artery diameter, in millimeters.
Change in Blood Pressure from Pre-Drive to During-Drive and Post-drive
时间窗: 10 minutes before driving session; 15, 30, 45, 60, 75, 90, 100, 120 minutes following start of (120 minute) driving session; 10 minutes, 1.5 hours, 3.5 hours, 6 hours, 24 hours after end of driving session.
systolic and diastolic blood pressure measured in mmHg
Change in Retinal Arteriolar Diameter from Pre-Drive to Post-Drive
时间窗: 30 minutes before 120 minute driving session; 30 minutes post driving session
measured by retinal photography, image analysis, in micrometers
Gene Expression and DNA methylation
时间窗: 30 minutes before 120 minute driving session; 30 minutes, 5 hour, and 24 hours post-driving session
analysis in circulating mononuclear cells; determined via fold change in abundance
次要结局
- inflammatory marker c-reactive protein(30 minutes before 120 minute driving session; 5 hour and 24 hours post-driving session)
- complete blood count with differential(30 minutes before 120 minute driving session; 5 hour and 24 hours post-driving session)
- inflammatory marker interleukin-6(30 minutes before 120 minute driving session; 5 hour and 24 hours post-driving session)
- circulating stress hormone(30 minutes before 120 minute driving session; 5 hour and 24 hours post-driving session)
研究者
Joel Daniel Kaufman
Professor, Environmental & Occupational Health Sciences
University of Washington