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Clinical Trials/NCT01388998
NCT01388998
Completed
Not Applicable

External Pressure Applied on the Caval Vein and Its Effects on Difference in Pulse Pressure (dPP) and Pleth Variability Index (PVI)

Johannes Gutenberg University Mainz1 site in 1 country24 target enrollmentJanuary 2011

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Intravascular Volume
Sponsor
Johannes Gutenberg University Mainz
Enrollment
24
Locations
1
Primary Endpoint
Change of dPP from start of intervention to 2 minutes after start of the intervention
Status
Completed
Last Updated
14 years ago

Overview

Brief Summary

Fluid therapy optimization in the perioperative period has been considered as major contributor to improve oxygen delivery. A recent, noninvasive approach to estimate fluid requirements in the anesthetized patient with arterial line is the assessment of difference in pulse pressure (dPP). Intraoperative fluid management by dPP is a goal-directed fluid management approach to avoid both hypervolemia and hypovolemia. However, several clinical factors may impede dPP measurements. Surgical manipulations in abdominal procedures may interfere with hemodynamic stability due to obstruction of the caval vein. Physiological considerations make us hypothesize that only intense pressure impedes caval blood flow and thus hemodynamics and dPP. Therefore, the investigators want to assess those changes after standardized application of three different pressure levels (2 N, 5 N, 10 N) on the caval vein.

Registry
clinicaltrials.gov
Start Date
January 2011
End Date
January 2012
Last Updated
14 years ago
Study Type
Interventional
Study Design
Crossover
Sex
All

Investigators

Sponsor
Johannes Gutenberg University Mainz
Responsible Party
Principal Investigator
Principal Investigator

Lydia T. Strys

M.D.

Johannes Gutenberg University Mainz

Eligibility Criteria

Inclusion Criteria

  • Patients scheduled for elective hepatic surgery procedures (hemihepatectomy) qualifying for arterial line

Exclusion Criteria

  • pregnancy
  • cardiac insufficiency (NYHA 4, EF \< 25 %)
  • coronary (CCS 4)
  • coagulopathy
  • symptoms of infection or sepsis
  • malignant hyperthermia
  • porphyria
  • oesophageal varicose veins
  • absence of sinus rhythm

Outcomes

Primary Outcomes

Change of dPP from start of intervention to 2 minutes after start of the intervention

Time Frame: Application of pressure for 2 minutes

Study Sites (1)

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