Evaluation of Hemodynamic Changes Induced by Alveolar Recruitment Maneuver With Respect to Volemic State in Patients Undergoing Anesthesia for Colon Surgery
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Hypovolemic indicator
研究概览
简要总结
Intraoperative hemodynamic management is important, since even mild variations in circulatory volume can be extremely damaging for patients.
Minimally invasive hemodynamic monitoring are not always available or cost-effective, therefore management of fluids is challenging for anesthesiologists.
This study aims to assess if, after performance of a lung recruitment maneuver (LRM), standard parameter's variation differs between hypovolemic and normovolemic patients.
Patients' volemic state will be assessed with the Vigileo system. Standard monitoring values (heart rate, invasive blood pressure and saturation) will be registered before and after LRMs.
A fluid challenge will be performed and the above mentioned parameters will be recorded again, after a second LRM.
The study is a prospective observational study.
详细描述
During general anesthesia, it's important to maintain normovolemia, since hypovolemia can cause inadequate tissue perfusion and hypervolemia increases the rate of complications, overall mortality and morbidity.
Critically ill patients commonly present with important hypotension that, in the majority of cases, is promptly treated with intravenous fluids to reverse organ hypoperfusion.
However, previous studies have demonstrated that only 50% of hemodynamically unstable patients are responsive to fluid administration.
In the last decade, attention has been focused on finding a parameter capable of assessing fluid responsiveness in a hypotensive patient.
Recent articles have demonstrated that standard monitoring parameters have no significance for this purpose, while hemodynamic parameters, like stroke volume variation (SVV) or pulse pressure variation (PVV) may have an important role.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age >18 years
- •Elective surgery
- •ASA score 1-2-3
- •Informed consent
排除标准
- •Pregnancy
- •Relevant cardiac/pulmonary comorbidities
- •Cardiac/kidney failure
- •Haemodynamic shock
结局指标
主要结局
Hypovolemic indicator
时间窗: Intraoperative
Finding an hypovolemic indicator among standard monitoring parameters
次要结局
未报告次要终点
研究者
Marco Gemma
Principal Investigator
IRCCS San Raffaele
