Human CYP2B6: Induction by Ethanol and Polymorphisms
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
研究概览
简要总结
The two purposes of this study are
-
to determine what effect the chronic and moderate/heavy drinking of alcoholic beverages has
-
on the blood level of bupropion and chlorzoxazone and their major breakdown products in the blood and
-
on the stimulant effect of bupropion and
-
to determine what effect a normal and common (25% frequency) genetic variation of a specific liver enzyme (that breaks down bupropion) has
-
on the blood levels of bupropion and its major breakdown products in the blood and
-
on the stimulant effect of bupropion.
Two groups of volunteers will be recruited for this study:
- volunteers who drink moderate to heavy amounts of alcohol frequently and
- volunteers who usually do not drink alcohol.
Volunteers will NOT be asked to change their drinking (or nondrinking) habits during the study.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy adults who are 21 - 55 years of age.
- •Either 1) Moderate-to-heavy drinkers who drink on average more than 14 but less than 28 drinks per week; OR 2) adults who normally abstain from drinking alcohol.
排除标准
- •Participants who are currently taking prescription medications (including oral contraceptives)
- •Pregnancy
- •Body mass index (BMI) greater than 30
- •History of seizures or eating disorders
研究组 & 干预措施
Trial Withdrawn 2
Trial Withdrawn 2
干预措施: Trial Withdrawn 2 (Other)
Trial Withdrawn 1
Trial Withdrawn 1
干预措施: Trial Withdrawn 1 (Other)