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临床试验/NCT06260202
NCT06260202已完成不适用

Nutrition Under Noninvasive Ventilation in Critically Ill Patients: a Retrospective Monocentric Analysis

Università degli Studi del Piemonte Orientale Amedeo Avogadro1 个研究点 分布在 1 个国家目标入组 112 人开始时间: 2024年3月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
112
试验地点
1
主要终点
Caloric and protein gap

研究概览

简要总结

Even though nutrition is a fundamental component of Intensive care unit (ICU) therapy, critically ill patients are frequently malnourished, a factor well known for its strong association with a higher risk of complications, prolonged ICU/hospital length of stay, and greater ICU readmission and mortality rates. Noninvasive ventilation (NIV) use has increased considerably over the past twenty years, making this supportive technique a keystone of acute respiratory failure (ARF) treatment. In this setting, respiratory support is provided through an interface, usually a mask or a helmet, that frequently represents an important obstacle to nutrition delivery, making oral intake impossible and posing the necessity to start enteral (EN) or parenteral nutrition (PN). Moreover, while critical care guidelines regarding nutritional management of patients receiving mechanical ventilation (MV) are well established, data and recommendations about the appropriate nutritional support to patients in NIV are still very limited. Due to this limited data, we want to describe characteristics and nutritional management of patients undergoing NIV in ICU, and to evaluate the difference between the mean caloric and protein intake of these patients and the recommended caloric and protein target for critically ill patients. Secondarily, we want to evaluate the difference of the caloric and protein intake among groups of patients undergoing different nutritional modality and to assess potential associations of the nutritional characteristics with patient outcomes.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Adult patients;
  • Admission to the Intensive Care Unit of Maggiore della Carità University Hospital from March 1st 2020 to February 28th 2023;
  • Noninvasive ventilation treatment for acute respiratory failure of any cause;
  • Duration of noninvasive ventilation treatment of more than two days;
  • Informed consent signed.

排除标准

  • Patients under 18 years of age;
  • Duration of noninvasive ventilation treatment of less than two days.

结局指标

主要结局

Caloric and protein gap

时间窗: At ICU discharge, a median of six days

to evaluate the difference between the mean caloric and protein intake of these patients and the recommended caloric and protein target for critically ill patients for every day of ICU stay

次要结局

  • Nutrition modalities outcomes(At ICU discharge, a median of six days)

研究者

发起方
Università degli Studi del Piemonte Orientale Amedeo Avogadro
申办方类型
Other
责任方
Principal Investigator
主要研究者

Francesca Moretto

Principal Investigator

Università degli Studi del Piemonte Orientale Amedeo Avogadro

研究点 (1)

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