Factors Associated With Complications of Cervical Necrotizing Fasciitis
试验速览
- 阶段
- 不适用
- 入组人数
- 350
- 试验地点
- 1
- 主要终点
- incidence of mediastinitis
研究概览
简要总结
Cervical necrotizing fasciitis (CNF) is a rare but severe complication of pharyngeal or dental infections. The infection can rapidly descend into the mediastinum and lead to a life-threatening prognosis. Treatment consists of a multidisciplinary approach in intensive care with radiologist and with early and repeated surgical debridement. Anti-inflammatory drugs have been incriminated by authors in the development of necrotizing fasciitis. Recently, a single-center study demonstrated that pharyngeal source of CNF and oral glucocorticoid intake before admission was associated with the occurrence of mediastinitis.
The aim of the study is to assess the incidence and factors associated with CNF complications, in particular mediastinitis. Secondary outcome is to describe patient characteristics, medical and surgical management.
Methods: A retrospective, observational, non-interventional multicentre study is conducted in nine intensive care units in France from January 2005 to December 2016.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient admitted in ICU for management of cervical necrotizing fasciitis between 2005 and 2016.
排除标准
- •Patients admitted in ICU for management of cervical abscess without cervical necrotizing fasciitis
- •Age < 18 years
结局指标
主要结局
incidence of mediastinitis
时间窗: At the entry in ICU (Day 1)
Computed tomography (CT) is performed at admission. Mediastinitis is described on CT finding.
次要结局
- factors associated with mediastinitis(At the entry in ICU (Day 1))