Impact of Remote Ischemic Conditioning in Patients Undergoing Primary Percutaneous Coronary Intervention
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 2
- 试验地点
- 2
- 主要终点
- Cardiac death
研究概览
简要总结
This study aimed to detect the effects of remote ischemic conditioning on infarct size, global contractility, morbidity, mortality, and renal function in patients undergoing primary percutaneous coronary intervention.
详细描述
Myocardial infarction (MI) generally refers to segmental (regional) myocardial necrosis, typically endocardial in location, secondary to occlusion of an epicardial artery.
Primary percutaneous coronary intervention (PPCI) is a reperfusion therapy that is carried out in patients who usually have ST-segment elevation MI (STEMI) within a specific time window.
During ischemia, metabolic acidosis occurs due to anaerobic metabolism, and ischemic injury ensues. After restoration of blood supply, reactive oxygen species (ROS) production and local inflammation increase secondary injury.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age more than 18 and less than 75 years old.
- •Both sexes.
- •Patients with new ST-segment elevation at the J-point in V1:V6 leads with the cut-point: ≥ 1mm other than leads V2-V3 where the following cut-points apply: ≥ 2mm in men ≥ 40 years; ≥ 2.5mm in men < 40 years, or ≥ 1.5mm in women regardless of age.
- •Patients with new left bundle branch block (LBBB).
排除标准
- •ST-segment elevation myocardial infarction (STEMI) with cardiogenic shock.
- •Severe comorbidities (uncontrolled hypertension, morbid obesity, recent cerebrovascular stroke, respiratory failure, sepsis, and stage 4 & 5 malignancy).
- •End-stage renal disease on hemodialysis.
- •Previous coronary artery bypass graft surgery (CABG).
- •Myocardial infarct within the previous 30 days.
- •Multi-vessel coronary artery disease.
- •Failure of culprit vessel recanalization.
- •Conditions precluding use of remote conditioning ie: paresis of upper limb.
- •Life expectancy of less than 1 year due to a non-cardiac pathology.
- •Patients who receive nephrotoxic drugs such as non-steroidal anti-inflammatory drugs and aminoglycosides.
结局指标
主要结局
Cardiac death
时间窗: 1 month post-procedure
Incidence of cardiac death was recorded.
次要结局
- Hospitalization for heart failure(1 month post-procedure)
- Contrast induced nephropathy(1 month post-procedure)
- Incidence of adverse events(1 month post-procedure)
- Renal impairment(1 month post-procedure)
研究者
Ahmed Yousry Mousa
Resident of Cardiology, Helwan University, Helwan, Egypt
Helwan University