Periodontal Disease and Colorectal Cancer

Not Applicable

Completed

• Conditions: Periodontal Diseases; Colorectal Carcinoma

• Registration Number: NCT06799182
• Lead Sponsor: University Medical Centre Ljubljana

Brief Summary

The aim of this interventional study is to determine the impact of periodontal disease and periodontal treatment on patients with colorectal cancer.

The main questions were:

1. Does periodontal treatment affect the levels of C-reactive protein in the blood of patients undergoing cancer treatment?

2. Can the investigators isolate periodontal pathogenic bacteria Fusobacterium nucleatum and Porphyromonas gingivalis from the mucosa of cancerous colon tissue using the method of quantitative culture?

The investigators will compare the levels of C-reactive protein in the blood of patients undergoing treatment for colorectal cancer who have received periodontal treatment with patients who have not received periodontal treatment. CRP levels will be measured during the first examination with the oncological surgeon, on the first and second day after the surgical procedure, and during the first follow-up with the oncological surgeon.

Additionally, the investigators collected samples of cancerous colon mucosa from 10 participants for the attempt to isolate F. nucleatum and P. gingivalis using the quantitative culture method.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-10-25
• Primary Completion: 2024-09-30
• Status Verified: 2024-11
• Study Completion: 2024-11-05
• Study First Submitted: 2025-01-15
• Study First Submitted QC: 2025-01-22
• Last Update Submitted: 2025-01-22
• Study First Posted: 2025-01-29
• Last Update Posted: 2025-01-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• colorectal cancer, scheduled for surgical treatment
• consent to participate

Additional inclusion Criteria fot the control group:

• fiilled questionnaire
• Recorded CRP results at the first examination, after surgery, and at the first follow-up examination.

Exclusion Criteria

• under 18 years old
• periodontal treatment in the past 12 months
• antibiotic therapy in the last 3 months
• edentulism
• advanced stage cancer, scheduled for palliative care
• chemotherapy or radiotherapy prior to surgical procedure

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
CRP levels	From the enrollment to the date of first documented progression at 16 weeks	Measurement of CRP levels in the blood of patients with colorectal cancer at the first examination by the oncological surgeon, on the first and second day after colon resection, and at the first follow-up examination by the oncological surgeon.
The proportion of Fusobacterium nucleatum and Porphyromonas gingivalis	From the first dental exam to the resective colon surgery at 2 weeks	Using quantitative culture for detection of periodontal bacteria Fusobacterium nucleatum and Porphyromonas gingivalis in the cancer altered intestinal musoca and comparing it with the status in the periodontal pocket

Trial Locations

Locations (1)

University Medical Center Ljubljana, Division of stomatology, Center for oral disease and periodontology; 🇸🇮 Ljubljana, Slovenija, Slovenia