Rehabilitation of Working Memory After Traumatic Brain Injury: Pilot Study of Brain Plasticity in Multimodal Advanced MRI
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Traumatic Brain Injury
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- working memory questionnaire
- Last Updated
- 8 years ago
Overview
Brief Summary
The aim of this study is to assess the brain correlates, as assessed with multimodal MRI, of working memory training in patients with severe traumatic brain injury (TBI)
Detailed Description
This is a pilot feasibility study. Patients with subacute/chronic (\> 6 months) severe TBI will be included if they suffer from a deficit in working memory. They will receive a specific hierarchical training of working memory (3 sessions per week during three months), according to a previously described methodology. A multimodal MRI will be performed at neuroSpin center (CEA, Orsay, France) before and after cognitive training, including: structural imaging (T1, FLAIR and diffusion tensor imaging, DTI); functional connectivity at rest; and functional activation during a working memory task (n-back). Behavioral and imaging changes after training will be analysed individually and compared to a group of healthy controls matched for age, gender and education.
Investigators
Eligibility Criteria
Inclusion Criteria
- •moderate to severe traumatic brain injury
- •6 months or more after the injury
- •working memory deficit on cognitive testing
Exclusion Criteria
- •previous neurological or psychiatric condition
- •severe behavioral troubles
- •contra-indication to MRI
- •pregnancy
Outcomes
Primary Outcomes
working memory questionnaire
Time Frame: change from baseline to 3 months
It is a self-assessment questionnaire comprising 30 questions scored on a five-point Likert scale, ranging from 0 ("no problem at all") to 4 ("very severe problem in everyday life"). The total score will be used.
Secondary Outcomes
- working memory testing(change from baseline to 3 months)
- neuro-imaging changes(change from baseline to 3 months)