The Influence of Prone Position for Spinal Surgery on Visual Acuity, a Comparison of Volatile Anesthesia With Desflurane to Total Intravenous Anesthesia With Propofol
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Visual injury
Study Overview
Brief Summary
This study investigated the effect of desflurane and propofol anesthesia on visual acuity in patients in prone position for spinal surgery. Many trials have investigated the effects of different anesthetic agents on intraocular pressure, propofol may reduce intraocular pressure more than other intravenous anesthetics.
Detailed Description
Perioperative increase in intraocular pressure can be caused by prone positioning. In addition to surgical factors, patients with glaucoma, uncontrolled hypertension, arthrosclerosis, and morbid obesity are at risk for potentially damaging optic nerve and loss of optic nerve function. Some studies found that intraocular pressure values were significantly lower in patients undergoing propofol total intravenous anesthesia than in patients undergoing desflurane anesthesia during intraoperative positional changes. Pronounced vasodilatation caused by desflurane might produced hyperaemia with higher intraocular pressure. Hemodynamic response to prone position measured by near-infrared spectroscopy (NIRS) on the prefrontal cortex could determine changes caused by prone position.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Triple (Participant, Care Provider, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Glasgow Coma scale 15
- •American Society of Anesthesiologists (ASA) Physical Status Classification System I-III
- •spinal surgery in duration less than 3 hours
- •sinus rhythm
Exclusion Criteria
- •postoperative artificial ventilation
- •serious neurological disease
- •lung disease with hypercapnia
- •propofol allergy
Arms & Interventions
Desflurane Group
Induction and anesthesia will be held by using desflurane
Intervention: Desflurane Group (Procedure)
Propofol Group
Induction and anesthesia will be held by using target-control anesthesia with propofol
Intervention: Propofol Group (Procedure)
Outcomes
Primary Outcomes
Visual injury
Time Frame: 48 hours
worsening of test for visual acuity (Rodenstock)
Secondary Outcomes
No secondary outcomes reported
Investigators
Dostalova Vlasta, MD, PhD
Principal Investigator
University Hospital Hradec Kralove