The Treatment of Magnesium Sulfate and Nifedipine in Preterm Labor Threat
Not Applicable
- Conditions
- Preterm Labor Without DeliveryPregnancy Preterm
- Interventions
- Registration Number
- NCT05520021
- Lead Sponsor
- Konya Meram State Hospital
- Brief Summary
Comparison of the effects of Nifedipine and MgSO4 therapies on maternal and fetal blood flow.
- Detailed Description
In this study, the investigators aim to compare the effect of Nifedipine and MgSO4 therapies on Doppler parameters of the uterine, umbilical, middle cerebral arteries, and ductus venous in the first 48 hours of therapy in pregnancies with preterm labor threat and also compare perinatal outcomes after delivery between the groups.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 30
Inclusion Criteria
- pregnancies with preterm labor threat between 28-34 weeks gestational ages
Exclusion Criteria
- Cervical dilatation at > 4 cm and/or cervical effacement >80%,
- Multiple pregnancies,
- Pregnancy complications including preeclampsia, ablatio placenta, intrauterine growth restriction, placenta previa, gestational diabetes
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Magnesium sulfate treatment Magnesium sulfate A total of 30 pregnancies with preterm labor threats will be treated with Magnesium sulfate. Nifedipine treatment Nifedipine A total of 30 pregnancies with preterm labor threats will be treated with Nifedipine.
- Primary Outcome Measures
Name Time Method Doppler parameters Gestational age at delivery (weeks) Pulsality index of middle cerebral artery.
- Secondary Outcome Measures
Name Time Method Perinatal outcomes Gestational age at delivery (weeks) NICU admission
Trial Locations
- Locations (1)
Hasan Ali Inal
🇹🇷Antalya, Turkey