Effects of Flywheel Resistance Training on Cognitive Function in Stroke Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 29
- 试验地点
- 1
- 主要终点
- Change from baseline in Cognitive Function at 3 months
研究概览
简要总结
Forty patients will be assigned to either a training group (12 wk unilateral knee extension flywheel resistance exercise; 4 sets of 7 reps 2 days/week) or a control group. Patients will maintain daily routines and any prescribed rehabilitation program. Established methods to assess muscle and cognitive function will be employed before and after the intervention.
This project will disclose whether an exercise paradigm, known to improve muscle function and increase muscle volume in healthy populations, will induce similar adaptations in chronic stroke patients. More importantly, this study will elucidate if any impairment in cognitive function caused by stroke, can be reversed with this particular resistance exercise regimen.
The information gained from this project will have significant implications and aid in advancing rehabilitation programs and exercise prescriptions for men and women suffering from stroke. The overall objective of this research is to promote independence and hence quality of life in these patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Mild-moderate hemiparetic gait
- •> 6 months post-stroke
- •Able to perform flywheel leg-press exercise
排除标准
- •Unstable angina
- •Congestive heart failure
- •Severe arterial disease
- •Major depression
- •Chronic pain
- •Psychotic alterations
研究组 & 干预措施
Flywheel leg-press resistance exercise
Participants from the resistance exercise group will perform a 12-wk unilateral flywheel resistance training program with the paretic limb. Four sets of seven coupled concentric and eccentric actions will be completed in the leg press device using flywheel technology twice weekly. Power in each set and repetition will be measured. During all training sessions, subjects will receive visual real-time feedback of power and force produced during each concentric-eccentric action.
干预措施: Flywheel leg-press resistance exercise (Other)
Control
Daily routines
结局指标
主要结局
Change from baseline in Cognitive Function at 3 months
时间窗: Baseline, Month 3
Cognitive function will be assessed before and after the training period in all participants. In a 60-90 min session, with 10 min of rest is needed, validated tests will be used to evaluate different domains of cognitive function: Speed of information processing; Short- and long-term memory; Attention; Language; Learning; Delayed recall; Working memory; Inhibition; Visuo-motor scanning; Dual task attention; Quality of life.
Change from baseline in Functional Performance at 3 months
时间窗: Baseline, Month 3
Up-and-Go, Fast Gait Speed, Berg Balance Scale
Change from baseline in Muscle Function at 3 months
时间窗: Baseline, Month 3
Isometric and dynamic force, and peak power during flywheel leg-press exercise. Quadriceps muscle volume (MRI).
次要结局
- Change from baseline in Spasticity at 3 months(Baseline, Month 3)
研究者
Rodrigo Fernandez Gonzalo
Ph.D.
Karolinska Institutet