Mechanisms of Anxiety and Depression Study

Completed

• Conditions: Anxiety; Depression

• Registration Number: NCT03135756
• Lead Sponsor: Palo Alto University

Brief Summary

Eligible participants will come in for three separate visits in which they will be interviewed, perform a variety of tasks, and undergo a non-invasive MRI scan. The investigators anticipate that (1) participants with anxiety and depression will likely perform differently than the healthy controls on cognitive tasks, (2) participants with anxiety and depression will likely show differences in brain functionality compared to the healthy controls, and (3) depression and anxiety likely share some underlying mechanisms.

Detailed Description

In order to determine eligibility, a brief phone screen lasting approximately 15 minutes will be conducted. If participants are eligible, they will be asked to come in for three separate visits. During the first visit, participants will complete questionnaires as well as a structured interview with one of the study's staff members at Palo Alto University in Los Altos. During the second visit, participants would come to Palo Alto University in Los Altos and complete questionnaires as well as a testing session involving various tasks. During the third visit, participants would undergo a non-invasive brain scan in which participants would complete a task as well as various questionnaires at Stanford University in Stanford.

The investigators have flexible hours and can work around participants' schedules! To inquire more about participation, participants can either email the investigators at paloalto.study@gmail.com or call the investigators at (650) 417-2000 ext. 3642

Study Timeline

• Study Start: 2015-03-19
• Study First Submitted: 2017-04-21
• Study First Submitted QC: 2017-04-26
• Study First Posted: 2017-05-01
• Primary Completion: 2018-03-14
• Study Completion: 2018-03-14
• Status Verified: 2018-05
• Last Update Submitted: 2018-05-09
• Last Update Posted: 2018-05-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 63

Inclusion Criteria

• Right-handed
• Healthy with no medical conditions OR have a history of anxiety and/or depression
• Ability to travel to both Palo Alto University and Stanford University

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Brain imaging	Day 1	Non-invasive MRI brain scan to see function and structure of brain
Assessment of symptoms and daily functioning	Day 1	Structured Clinical Interview for DSM-IV, General demographic questionnaires, Penn State Worry Questionnaire, Intolerance of Uncertainty Questionnaire, The Positive and Negative Affect Schedule, Behavioral Inhibition Scale/Behavioral Activation Scale, The NEO Five-Factor Inventory, Mood and Anxiety Symptom Questionnaire, Alcohol Use Disorders Identification Test, Behavioral Regulation Index and Metacognition Index, General temperament Survey, Questionnaire of Mental Imagery, Rumination Reflection Questionnaire, Drug Abuse Screening Test, Childhood Trauma Questionnaire- Factor Structure, Emotion Regulation Questionnaire, Trait Meta-Mood Scale
Cognitive assessment	Day 1	Objective assessment of cognitive strengths and weaknesses via neuropsychological testing session

Trial Locations

Locations (2)

Palo Alto University; 🇺🇸 Los Altos, California, United States

Stanford University; 🇺🇸 Stanford, California, United States