Association Between the Use of Pulmonary Artery Catheter and Clinical Outcomes After Liver Transplantation
试验速览
- 阶段
- 不适用
- 入组人数
- 1,970
- 试验地点
- 1
- 主要终点
- Number of Participants with acute kidney injury
研究概览
简要总结
The investigators attempted to evaluate whether the use of PAC is associated with better clinical outcomes after liver transplantation compared with the case without PAC.
详细描述
Pulmonary artery catheter (PAC) has been used for advanced hemodynamic monitoring during liver transplantation. However, recent advances in less invasive monitoring could provide continuous cardiac output monitoring by arterial waveform analysis. Using this technology, stroke volume variation (SVV) is monitored as a preload index. Calculated systemic vascular resistance (SVR) can be monitored if central venous pressure (CVP) is provided. Therefore, this less invasive form of hemodynamic monitoring may replace the PAC. The investigators attempted to evaluate whether the use of PAC is associated with better clinical outcomes after liver transplantation compared with the case without PAC.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients who underwent living or deceased donor liver transplantation at our tertiary care university hospital between 2006 and 2022
排除标准
- •Patients with baseline renal dysfunction
- •Missing baseline or outcome variables
- •Retransplantation
- •Patients who received intraoperative transesophageal echocardiography (TEE) monitoring
结局指标
主要结局
Number of Participants with acute kidney injury
时间窗: the first 7 postoperative days
Acute kidney injury (AKI) was defined by the Kidney Disease Improving Global Outcomes (KDIGO) criteria, which was defined according to the greatest change in serum creatinine level during the postoperative seven days (Stage 1: more than 1.5-fold; stage 2: more than 2-fold; stage 3: more than 3-fold increase from baseline level or increase in serum creatinine to ≥ 4.0 mg/dL or the initiation of renal replacement therapy). The most recent serum creatinine level measured before surgery was collected as a baseline value.
Number of Participants with early allograft dysfunction
时间窗: the first 7 postoperative days
Early allograft dysfunction (EAD) was defined when one or more of the following are present within the first 7 postoperative days: total bilirubin ≥ 10 mg/dL, prothrombin time: international normalized ratio ≥ 1.6, or aspartate or alanine transaminase \> 2000 IU/L
次要结局
- In-hospital mortality(the first month after admission)
- One-year mortality(one year after transplantation)
- Length of intensive care unit (ICU) stay(the first month after admission)
- Length of hospital stay(the first month after admission)
研究者
Won Ho Kim, MD
Professor
Seoul National University Hospital