Impact of sarcopenia on clinical outcomes for patients with resected hepatocellular carcinoma: A retrospective comparison of eastern and western cohorts
Not Applicable
- Conditions
- Patients who underwent liver resection for hepatocellular carcinoma.
- Registration Number
- JPRN-UMIN000049970
- Lead Sponsor
- Okayama University Hospital
- Brief Summary
The predictive performance of sarcopenia for both short-term and long-term outcomes was higher in JP compared to NL (maximum C-index: 0.58 vs. 0.55, respectively). However, differences between cutoff values were small. For the association between sarcopenia and OS, a strong association was found in JP [hazard ratio (HR) 2.00, 95% CI [1.230-3.08], P =0.002], where this was not found in NL (0.76 [0.42-1.36], P =0.351).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 700
Inclusion Criteria
Not provided
Exclusion Criteria
Patients were excluded if: HCC was not confirmed upon histopathological examination or if no preoperative computed tomography (CT) scan was available within three months prior to the resection.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome was overall survival (OS), defined as the time in days between the date of resection and the date of death or last follow-up.
- Secondary Outcome Measures
Name Time Method We investigated short-term outcome measures: recurrence free survival (RFS), length of hospital stay, complications with Clavien-Dindo grade (CD) > 2, and 90-day mortality.