Evaluation of Postoperative Pain After Using Ibuprofen, Nitrofurantoin, or Calcium Hydroxide as Intracanal Medicaments in Root Canal Treatment of Necrotic Mandibular Posterior Teeth. A Randomized Controlled Trial
Trial Snapshot
- Phase
- Phase 1
- Status
- Recruiting
- Sponsor
- Cairo University
- Enrollment
- 111
- Locations
- 1
Study Overview
Brief Summary
The aim of this study is to assess the effect of ibuprofen, nitrofurantoin, and calcium hydroxide on postoperative pain after endodontic treatment of necrotic mandibular posterior teeth
Research question/hypothesis:
In patients with necrotic pulps in their mandibular posterior teeth, there would be no difference in the incidence and/or severity of postoperative pain after the use of ibuprofen, nitrofurantoin, or calcium hydroxide intracanal medications.
The study will evaluate postoperative pain after using either of the tested drugs as an intracanal medication amidst visits. of endodontic treatment in cases where pulp necrosis is confirmed.
Detailed Description
-
Trial design:
-
A Randomized controlled, double-blind, parallel-arm, clinical trial.
-
Allocation ratio 1:1:1
-
Framework: superiority
-
Study settings:
Outpatient clinic of Endodontics at the Faculty of Dentistry, Egyptian Russian University, Badr city, Cairo governorate, Egypt.
-
Eligibility criteria
-
Inclusion criteria:
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Double (Participant, Outcomes Assessor)
Masking Description
Masking Description
Eligibility Criteria
- Ages
- 18 Years to 40 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Patients with necrotic pulps.
- •Adult, healthy patients, older than 18 years old
- •Males and females.
- •Patient with the ability to understand and use pain scales.
- •Patient who accepts enroll to the study.
Exclusion Criteria
- •Patients' allergies or any other contraindication to any of the medications used.
- •Pregnant and lactating females.
- •Patients have been taking pain medication 12 hours earlier.
- •Patients who have more than one symptomatic mandibular tooth in the same quadrant.
- •Patients with contributory medical history (ASA>II).
Arms & Interventions
calcium hydroxide
Intervention: Calcium Hydroxide (Drug)
ibuprofen
Ibuprofen. a NSAID, will be ground and formed into a paste to be placed inside the root canals of necrotic mandibular posterior teeth, to explore its effects on post-operative pain
Intervention: ibuprofen (Drug)
nitrofurantoin
Intervention: Nitrofurantoin (Drug)
Investigators
Maha Nasr
Assistant Professor
Cairo University