Evaluation of Paternal, Maternal and Obstetric Factors Leading to the Hepatitis B Immunization Failure in Hong Kong
Completed
- Conditions
- Hepatitis B Infection
- Registration Number
- NCT02443233
- Lead Sponsor
- The University of Hong Kong
- Brief Summary
Globally, hepatitis B virus (HBV) infection is the most common form of chronic hepatitis. There are still a lot of uncertainties on how infants acquired HBV leading to the development of chronic HBV infection despite active and passive immunoprophylaxis. The investigators would like to carry out a prospective study to answer the following questions:
1. the paternal, maternal and obstetric factors leading to immunoprophylaxis failure
2. the prevalence of immunoprophylaxis failure in Hong Kong
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 750
Inclusion Criteria
- All women age ≥ 18 years
- Maternal or paternal hepatitis B carrier
Exclusion Criteria
- Couples will be excluded if female partners of paternal hepatitis B carrier were occult carrier
- Plan to deliver in other units
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The effect of high maternal viral load on immunoprophylaxis failure, using 10^6 copies/ml as cut-off Infants' blood for HbsAg at 9-12 months old
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Obstetrics and Gynaecology
🇨🇳Hong Kong, Hong Kong, China