Effects of antihypertensive drugs on soluble (pro)renin receptor in hypertensive patients: open-label parallel-group controlled study
Not Applicable
Recruiting
- Conditions
- hypertension
- Registration Number
- JPRN-UMIN000006342
- Lead Sponsor
- Tokyo Women's Medical University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 2000
Inclusion Criteria
Not provided
Exclusion Criteria
1. Patient with chronic kidney disease (CKD) stage 4 or 5 2. Patient whom director of the study disqualified
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Blood and urine prorenin and soluble (pro)renin receptor
- Secondary Outcome Measures
Name Time Method 1. Blood tests: biochemical measurements, hormones, oxidative stress markers, inflammatory markers, renin 2. Urine tests: pH, albumin/creatinine, hormones, oxidative stress markers, renin 3. Imaging tests: X-rays, CT, MRI, echography 4. Physiological tests: ECG, flow-mediated dilataion(FMD), cardio-anke vascular index(CAVI), augmentaion index(AI), ankle-brachial index(ABI), 24 hours ambulatory blood pressure monitoring(ABPM), visceral/subcutaneous fat ratio measurement