Differences in antihypertensive drug levels in patients with hypertension: old vs young
Recruiting
- Conditions
- High blood pressure10057166
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 80
Inclusion Criteria
• Age between 18-50 years or > 70 years
• Start with the use of oral perindopril 2, 4 or 8 mg a day or losartan 25, 50
or 100 mg a day
• Us of oral perindopril 2, 4 or 8 mg a day or losartan 25, 50 or 100 mg a day
and availability of a 24-hour ABPM less than 1 year ago before the start of
perindopril or losartan AND no other changes in antihypertensive drug therapy.
• Providing informed consent after reading the patient information
Exclusion Criteria
• Not providing informed consent or not capable of giving informed consent,
• End-stage renal disease (eGFR<15 ml/min)
• Use of other antihypertensive drugs prescribed that are of influence on the
RAAS system incuding diuretics, beta blockers and other RAAS-inhibitors.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Our primary objective is to determine if there is a difference in exposure to<br /><br>losartan and perindopril measured with the (AUC) when comparing elderly (>70<br /><br>years) with younger patients (<50 years).</p><br>
- Secondary Outcome Measures
Name Time Method <p>We want to determine if there is a difference in the drop of blood pressure<br /><br>between older (>70 years) and younger (<50 years) patients; and if so, can this<br /><br>difference be explained by a difference in the plasma concentration of the<br /><br>drug. Furthermore, we want to investigate wat the influence is of the AUC on<br /><br>RAAS-activity during the use of perindopril or losartan. Lastly, we want to<br /><br>investigate if more parameters, besides age, are of influence on the AUC that<br /><br>can explain the possible difference. </p><br>