Comparison of Respiratory Muscle Strength, Physical Activity Level, and Dietary Habits in Individuals With Post-COVID-19 Syndrome Having Different Circadian Rhythms
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Respiratory Muscle Strength
研究概览
简要总结
Post-COVID-19 syndrome is associated with persistent symptoms such as fatigue, reduced physical activity, and impaired respiratory function. Circadian rhythm differences (chronotype) may influence lifestyle behaviors including physical activity, nutrition, and sleep patterns.
This observational cross-sectional study aims to compare respiratory muscle strength, physical activity levels, and nutritional habits among individuals with post-COVID-19 syndrome according to their chronotype (morning, intermediate, and evening types).
Additionally, genetic analysis of the CLOCK gene polymorphism will be performed to support objective evaluation of circadian rhythm differences. The findings of this study may help to better understand the role of circadian rhythm in post-COVID-19 syndrome and contribute to the development of individualized rehabilitation and lifestyle interventions.
详细描述
Post-COVID-19 syndrome is characterized by persistent symptoms such as fatigue, reduced exercise tolerance, and impaired respiratory function following acute SARS-CoV-2 infection. Emerging evidence suggests that circadian rhythm disruption may play a role in the pathophysiology of these symptoms by affecting metabolic regulation, hormonal balance, sleep quality, and physical performance.
Circadian rhythm varies between individuals and is commonly classified into chronotypes as morning, intermediate, and evening types. These chronotypes are associated with differences in daily activity patterns, nutritional behaviors, and physiological performance.
The aim of this observational cross-sectional study is to compare respiratory muscle strength, physical activity levels, nutritional habits, sleep quality, fatigue perception, and gastrointestinal symptoms in individuals with post-COVID-19 syndrome according to their chronotype.
Participants aged 18-65 years with a confirmed diagnosis of post-COVID-19 syndrome will be included. Chronotype will be assessed using the Munich Chronotype Questionnaire (MCTQ). Respiratory muscle strength will be evaluated using maximal inspiratory and expiratory pressures (MIP/MEP), and dynamic respiratory parameters will be assessed using a POWERbreathe device. Respiratory muscle endurance will be measured using threshold loading protocols.
Physical activity levels will be assessed using the International Physical Activity Questionnaire (IPAQ), while nutritional intake will be evaluated using 24-hour dietary recall. Sleep quality, fatigue severity, and gastrointestinal symptoms will be assessed using validated questionnaires.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosed with Post-COVID-19 Syndrome
- •Aged between 18-65 years
- •Able to read and understand Turkish
- •Voluntary participation
- •Classified as Post-Covid Functional Status Scale (PCFS) grade 2-3
- •Clinically stable condition
- •No uncontrolled comorbidities (e.g., hypertension, diabetes under control)
- •No orthopedic or neurological conditions affecting exercise testing
排除标准
- •Recent myocardial infarction or pulmonary embolism
- •Severe uncontrolled chronic diseases
- •Neurological or orthopedic conditions limiting mobility
- •Psychiatric or neurological disorders affecting cooperation or test compliance
- •Inability to complete assessments
研究组 & 干预措施
Evening Types (Owls)
People who stay up late, struggle with early mornings, and reach their peak functional capacity in the late afternoon or evening.
Morning Types (Larks)
People who wake up early, feel most energetic in the morning, and reach their peak performance early in the day.
结局指标
主要结局
Respiratory Muscle Strength
时间窗: Time Frame: Day 1
Maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP) values will be recorded with mouth pressure device.
Dynamic respiratory muscle strength
时间窗: Time Frame: Day 1
Respiratory muscle strength index (S index) will be assessed using a portable POWERbreathe K5 device.
Respiratory muscle endurance
时间窗: Time Frame: Day 1
Respiratory muscle endurance test at constant threshold load will be used.
次要结局
- Physical Activity Level(Time Frame: Day 1)
- Dietary Intake(Time Frame: Day 1)
- Chronotype Classification(Time Frame: Day 1)
- Fatigue Severity(Time Frame: Day 1)
- Gastrointestinal Symptoms(Time Frame: Day 1)
- Sleep Quality(Time Frame: Day 1)
- Classificationof human faeces forms(Time Frame: Day 1)
研究者
Ebru Calik
Professor
Hacettepe University