Improvements in insulin resistance caused by weight loss interventions

Suspended

• Conditions: Insulin resistance; Diabetes; Metabolic and Endocrine - Diabetes

• Registration Number: ACTRN12605000395639
• Lead Sponsor: The Wakefield clinic

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2005-09-14
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Suspended
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Patients presenting for gastric bypass and,BMI >35

Exclusion Criteria

Significant known heart disease; significant renal disease; known liver disease; Type 1 diabetes; and,Type 2 diabetes for more than 5 years.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Rates of decline for plasma glucose and free fatty acids will be calculated from the insulin tolerance test and compared . This is the measure of insulin resistance.[Before and after VLCD and gastric bypass]

Secondary Outcome Measures

Name	Time	Method
Body composition will be assessed using whole-body Dual-X-Ray Absorptiometry (DEXA).[This will allow accurate measurement of total fat mass and fat-free mass before VLCD and/or surgery and after six days VLCD and/or post-surgery.]