The effect of weight loss through a low calory diet on exercise induced bronchoconstriction in children with asthma and moderate overweight.

Completed

• Conditions: overgewicht; Asthma; obesity (heavy overweight); 10006436

• Registration Number: NL-OMON34483
• Lead Sponsor: Medisch Spectrum Twente

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

- Age between 8-18 years.
- Doctors diagnosis of mild to moderate asthma.
- Exercise induced asthma defined by a >10% exercise induced fall in FEV1.
- BMI score above or at the cut off points for overweight, based on international data and linked to the widely accepted adult cut off points of a body mass index of 25 kg/m2.
- Clinically stable period at least 3 weeks before the study period.
- Maximal FEV1 >70% of predicted value.

Exclusion Criteria

- Other pulmonary or cardiovascular illnesses.
- Genetic disorders.
- Maximal FEV1 <70% of predicted value.
- Use of long acting bronchodilators 24 hours before testing.
- Use of short acting bronchodilators 8 hours before testing

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Analyze the relation between the reduction in BMI and the reduction in exercise<br /><br>induced fall in FEV1. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary we analyze the relation between reduction in BMI and the recovery of<br /><br>the lungfunction to baseline, the increase in baseline FEV1, the reduction in<br /><br>FeNO, quality of life and the asthma control.</p><br>