Effects of acute dietary restriction on gut motor, hormone and energy intake responses to duodenal fat in obese me

Completed

• Conditions: Investigate the effects of 4-day very low calorie diet on gastrointestinal (GI) function and appetite, in obese subjects; Diet and Nutrition - Obesity

• Registration Number: ACTRN12610000083099
• Lead Sponsor: A/Prof Christine Feinle-Bisset

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-01-22
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 8

Inclusion Criteria

Subjects will all be males between age 18 -55 years, with a body mass index (BMI) of 30 - 35 kg/m2. Subjects will be required to consume less than 20g of alcohol per week, be non-smokers, free of gastrointestinal or chronic disease and not currently taking medication.

Exclusion Criteria

Each subject will be questioned prior to the study to exclude: (1)significant gastrointestinal symptoms; disease or surgery (2)current use of medications which may alter gastrointestinal motor function or appetite (3)diabetes mellitus (fasting glucose >6.9 mmol/l and/or glycated haemoglobin =6.2 %) (4)epilepsy (5)cardiovascular or respiratory disease (6)any other significant illness as assessed by the investigator (7)allergy to local anaesthetic (8)intake of > 20 g alcohol on a daily basis (9)smokers (10)individuals with food intolerances, allergies or vegetarians

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Antropyloroduodenal motility - During the 120 minute infusion antropyloduodenal motility will be assessed via changes in the pressures within the antrum, pylorus and duodenum which are captured by sensors on the catheter, and connected to a computer-based system, running commercially available hardware (Flexisoft)[At -15, 0, 15, 30, 45, 60, 75, 90, 120 min during the infusion period on each study day.];Hormone release - Cholecystokinin (CCK), Peptide YY (PYY) and ghrelin. Blood samples were drawn from subjects every 15 minutes until t=120, and then once more at t=150. Radioimmuno assays were used to determine the concentration of these hormones in plasma.[At -15, 0, 15, 30, 45, 60, 75, 90, 120 during the infusion period and 150 min on each study day]

Secondary Outcome Measures

Name	Time	Method
Energy intake- At t = 120 min the infusion will be discontinued, and the subject extubated and offered a cold buffet-style meal (t = 120 - 150 min). The meal will be weighted before and after consumption to for the assessment of energy intake using Foodworks[At 120 min after the infusion period on each study day]