A comparative clinical evaluation of efficacy of PRF and hydroxyapatite granules in surgical management of periapical pathological defects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- it was concluded that both the graft materials prf and hydroxyapatite were efficient in improving clinical parameters as well as regenerative effects when used in the treatment of periapical defect
研究概览
简要总结
For complete regeneration, delivery of growth factors in the local environment holds a great deal of adjunct to bone grafts. Platelet rich fibrin (PRF) is considered as second generation platelet concentrate, consisting of viable platelets, releasing various growth factors. Hence, this study aims to investigate the clinical and radiological (bone fill) effectiveness of autologous PRF and synthetic Hydroxyapatite granules in the treatment of periapical defect bony defects.
**Aim and Objective:**Comparison of the efficacy of PRF and HA bone grafts in periradicular surgery by clinical and radiographic evaluation.
Study Design/Methodology: A randomised clinical trial was conducted in patients who were assigned for periradicular surgery. 20 patients were included in this study and were divided into 2 groups. The patients were randomly assigned for the surgery, received synthetic HA graft and PRF obtained from the patient in the respective assigned groups. A clinical and radiographic evaluation was performed postoperatively at the period of 1 month, 3 months and 6 months.
**Results:**There was no statistical difference in clinical healing as well as reduction in defect size radiographically in both the groups. Although both the biomaterials were seen to enhance the rate of bone deposition and can be used as an adjuvant in the treatment of periapical defects.
Conclusion: It was concluded from the study that a good quality apical seal can be obtained using root‑end filling materials contributing to the success of the treatment. To further enhance the success rate, grafts, and various host modulating agents can be used. HA crystals used as grafts are bioactive materials that promote the formation of new bone. However, PRF is preferred over grafts as it is autologous and promotes faster healing by release of growth factors needed for the formation of bone
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •18 years and above of both sexes The tooth to be treated should have a periradicular lesion and for which nonsurgical treatment alone is considered insufficient or retreatment is considered unfeasible or had previously failed. Periapical pathology in anterior region of maxillary and mandibular region. The diameter of the bone defect, as will be determined from the intraoral periapical radiographs, should be up to 2 cm x 2cm in diameter.
排除标准
- •Patients in whom surgery is medically contraindicated.
- •Age less than 18 years.
- •Immuno-compromised and patients with metabolic disorders.
- •An active infection or a history of persistent infections.
- •The diameter of bony defect more than 2 cm× 2 cm as determined from the intra oral periapical radiograph.
结局指标
主要结局
it was concluded that both the graft materials prf and hydroxyapatite were efficient in improving clinical parameters as well as regenerative effects when used in the treatment of periapical defect
时间窗: it was concluded that both the graft materials prf and hydroxyapatite were efficient in improving clinical parameters as well as regenerative effects when used in the treatment of periapical defect
次要结局
未报告次要终点