The Efficacy of Autogenous Dentin Graft in Mandibular Wisdom Tooth Extraction

Not Applicable

Active, not recruiting

• Conditions: Periodontal Pocket; Trismus; Swelling Lips & Face; Pain, Acute
• Interventions: Procedure: Autogenous dentin graft

• Registration Number: NCT06073639
• Lead Sponsor: University of Medicine and Pharmacy at Ho Chi Minh City

Brief Summary

The study aimed to investigate clinical effect of autogenous dentin graft on patients following mandibular wisdom tooth extraction. The primary outcomes are pain, swelling, trismus and soft tissue healing index within one week after surgery. The investigators also measured periodontal healing of distal aspect of the adjacent second molar up to 2 year after the surgery.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-12-01
• Primary Completion: 2022-02-28
• Study First Submitted: 2023-09-25
• Status Verified: 2023-10
• Study First Submitted QC: 2023-10-05
• Last Update Submitted: 2023-10-05
• Study First Posted: 2023-10-10
• Last Update Posted: 2023-10-10
• Study Completion: 2024-02-28

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 13

Inclusion Criteria

• Over 18 years old
• Symmetry mandibular third molars
• Symmetry maxillary third molars with no caries or periodontal disease
• Mandibular second molars are available

Exclusion Criteria

• Systematic health has contraindication for surgery
• Pregnant or breastfeeding women
• Allergy with Lidocaine
• Abnormal signs surrounding mandibular third molars

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Dentin graft	Autogenous dentin graft	-

Primary Outcome Measures

Name	Time	Method
Rate of self-reported pain	3 days, 7 days	Pain is measured by self-reported Likert scale from 0 to 5. Higher score indicated more painful situation. Result is reported by the mean score.
Self-reported swelling	3 days, 7 days	Patients reported their perception about swelling levels. There are 6 levels of this scale, score from 0 to 5. Higher score means more swelling.
Aveolar height	7 days, 2 months, 6 months, 2 years	Aveolar height is measured as the distance from cementoenamel joint on distal surface of second molar to the aveolar ridge. The landmark points are defined on periapical film. The aveolar height is measured at 7 days, 3 months, 6 months and 2 years after the surgery.
Swelling measured by facial dimension	3 days, 7 days	Difference of distances of facial landmark points between post-and pre-operative wisdom tooth surgery. Two distances (AB and CD) from 4 landmark points are used for measurement: A - lateral commissure of the eye, B - gonion, C - tragus, and D - lateral commissure of the lips.
Trismus	3 days, 7 days	Trismus is measured by difference of maximal mouth opening between post-and pre-operative wisdom tooth surgery. Maximal mouth opening is mueasured by distance of mesial incisal edge of maxillary and mandibular central incisor.
Soft tissue healing score	3 days, 7 days, 30 days	The soft tissue healing score is evaluated according to Hamzami (2018). It includes 8 sub-items. Each item is recorded as 0 or 1 (score). Then, total score of the first 30 days (3 evaluation time) is used to classify wound healing level (good, acceptable, and bad).

Trial Locations

Locations (1)

Son Hoang Le; 🇻🇳 Ho Chi Minh City, District 5, Vietnam