Autogenous Demineralized Dentin Block Graft Versus Particulate Deproteinized Bovine Bone Graft for Alveolar Ridge Preservation

Not Applicable

• Conditions: Alveolar Bone Loss
• Interventions: Procedure: Alveolar ridge preservation using autogenous demineralized dentin block graft; Procedure: Alveolar ridge preservation using particulate deproteinized bovine bone graft

• Registration Number: NCT05374083
• Lead Sponsor: Cairo University

Brief Summary

The aim of this trial is to compare the effect of autogenous demineralized dentin block graft (ADDBG) versus particulate deproteinized bovine bone graft (PDBBG) on alveolar ridge preservation after extraction of non-restorable single rooted teeth

Detailed Description

Many studies have reported an approximately 50% reduction in alveolar bone both the horizontal and vertical directions over 12 months with more than two-thirds of the reduction occurring in the first three months after extraction. Alveolar ridge preservation is a procedure that attempts to reduce bone dimensional changes that naturally take place following tooth extraction. During the last decade, efforts have been made to confirm procedures that can prevent bone resorption after extraction. The use of bone grafts aim to promote bone healing and assist bone regeneration. Various types of materials are used for socket preservation, such as autogenous bone, allograft bone, xenograft materials, and alloplast materials. The deproteinized bovine bone has been tested in vitro and in vivo in the alveolar ridge preservation and plays a positive role in osteoconductive function. Guided bone regeneration (GBR) procedure has been developed to counteract alveolar ridge bone resorption. GBR technology with xenografts, such as the deproteinized bovine bone mineral, could lead to bone regeneration.

Moreover, root dentin block is composed of Type I collagen matrix with several osteoinductive non-collagenous proteins such as bone morphogenetic proteins (BMP) and dentin matrix proteins. Geometrically, alveolar bone morphology was maintained by dentin block graft as well as it has micropores (dentinal tubules) of 3-5 μm diameter and macropores of 0.2-0.3 mm diameter for enhancing osteoinductive and osteoconductive functions.

Both demineralized dentin block and particulate deproteinized bovine bone grafts with or without collagen membrane have been utilized for alveolar ridge preservation or augmentation but the superiority of one form over the other is not yet clear

Study Timeline

• Status Verified: 2022-05
• Study First Submitted: 2022-05-07
• Study First Submitted QC: 2022-05-11
• Last Update Submitted: 2022-05-11
• Study First Posted: 2022-05-16
• Last Update Posted: 2022-05-16
• Study Start: 2022-07
• Primary Completion: 2023-02
• Study Completion: 2023-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

• Non-restorable tooth indicated for extraction
• Single-rooted teeth
• Motivated patients, agree to sign informed consent and complete the follow-up period

Exclusion Criteria

• Pregnant females
• active infection at extraction site
• Smokers
• systemic conditions affecting healing (e.g. diabetes, medications as bisphosphonates...)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Alveolar ridge preservation using autogenous demineralized dentin block graft	Alveolar ridge preservation using autogenous demineralized dentin block graft	Atraumatic extraction of non-restorable teeth, then the extracted tooth will be prepared and demineralized using hydrochloric acid (HCL) acid as demineralized dentin block graft and inserted in the extraction socket and covered then suturing
Alveolar ridge preservation using particulate deproteinized bovine bone graft	Alveolar ridge preservation using particulate deproteinized bovine bone graft	Atraumatic extraction of non-restorable teeth, then the socket will be packed by particulate deproteinized bovine bone graft and covered then suturing

Primary Outcome Measures

Name	Time	Method
Alveolar ridge bucco-lingual width change in mm	6 months	Alveolar bone linear width will be measured at baseline and after 6 months using cone beam computed tomography (CBCT) scans. The change in bone width will be calculated as the subtraction of final width from baseline width and will be measured in millimetres

Secondary Outcome Measures

Name	Time	Method
Histological assessment	6 months	Bone samples from control and intervention sites will be taken during implant placement using a trephine bur of a size smaller than the implant. Samples will be examined for new bone formation (Yes/no).
Alveolar ridge apico-coronal height change in mm	6 months	Difference in height linear measurement between baseline and final CBCT scans

Trial Locations

Locations (1)

Faculty of dentistry; 🇪🇬 Cairo, Egypt