The role of the vascular wall in the salt and blood pressure homeostasis
- Conditions
- saltNaClsodiumsodium -and volume balanceblood pressureextracellular volumeendothelial surface layerglycocalyxnatriumzoutbloeddrukzout-en volume huishouding
- Registration Number
- NL-OMON24712
- Lead Sponsor
- Academic Medical Center
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 12
Inclusion Criteria
Healthy subjects (n=12)
-Male between 18 and 40 years of age
Exclusion Criteria
Subjects meeting any of the following exclusion criteria are not to be enrolled in the study:
-An office blood pressure >140/90 mmHg
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary endpoint will be the ECV as represented by the BP and Body Weight (BW) in response to a acute and chronic salt load, studied in healthy volunteers.<br><br><br>
- Secondary Outcome Measures
Name Time Method ESL will be assessed by three different (indirect) methods in association with different salt-conditions:<br /><br>-Volume of microvascular ESL (by Sidestream Darkfield (SDF) imaging as described in the methods section)<br /><br>-Transcapillary Escape Rate (TER-Alb) for measuring vascular permeability and determination of ESL function<br /><br>-ESL shedding products (heparan sulphate, hyalorunan, syndecan-1, hyloranudase activity)<br /><br>-GFR (determined with ioxehol)<br><br>