NL-OMON40170
Completed
Not Applicable
Role of endothelial surface layer in regulating the sodium balance and extracellular fluid volume - SALT study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- fysiologie van natrium- en volumebalans
- Sponsor
- Academisch Medisch Centrum
- Enrollment
- 18
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Healthy subjects
- •\- Male between 18 and 40 years of age
- •\- Healthy, as determined by a responsible and experienced physician, based on a medical evaluation including medical history, physical examination (PE) and laboratory tests carried out in the screening visit.
- •\- Non\-treated office blood pressure \* 140/90 mmHg
- •\- Capable of giving written informed consent and able to comply with the requirements and restrictions listed in the informed consent form
Exclusion Criteria
- •\- An office blood pressure \>140/90 mmHg
- •\- A body mass index \> 30 kg/m2
- •\- A major illness in the past 3 months or any significant chronic medical illness that the Investigator would deem unfavourable for enrolment, including chronic inflammatory diseases
- •\- A history of any type of malignancy within the past 5 years with the exception of successfully treated basal cell cancer of the skin
- •\- A history of any renal disease
- •\- A history of cardiovascular disease (in the past 6 months) defined as documented coronary artery disease including myocardial infarction, (un\-)stable angina pectoris or acute coronary syndrome, precutenaous transluminal coronary angioplasty, coronary artery bypass grafting, cerebrovascular disease including ischemic and hemorrhagic stroke or a subarachnodial bleeding, or peripheral artery disease including aortic aneurysmata
- •\- A history of coagulation disorders
- •\- A history of primary hyperlipoproteinemias
- •\- A history of hypersensitivity or allergy to iodium or to shell fish
- •\- A history, within 3 years, of drug abuse (including benzodiazepines, opioids, amphetamine, cocaine, THC, methamphetamine)
Outcomes
Primary Outcomes
Not specified
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