ChiCTR2100048750尚未招募Unknown
Neurobiological mechanisms underlying the effects of mindfulness-based intervention and Tai Chi Chuan on sleep disturbance in older people
General Research Fund1 个研究点 分布在 1 个国家目标入组 156 人开始时间: 2022年1月1日最近更新:
试验速览
- 阶段
- Unknown
- 状态
- 尚未招募
- 发起方
- 入组人数
- 156
- 试验地点
- 1
- 主要终点
- Subjective sleep quality
研究概览
简要总结
- To provide novel insight into the additive and synergistic effects of an mindfulness-based intervention (MBI) group and a Tai Chi Chuan (TCC) group for sleep disturbance in older people over a 12-month follow-up period by comparison to a sleep hygiene education (SHE) control group.
- To explore the lived experience of individuals in terms of sleep quality and the impact, if any, of different interventions.
- To provide empirical support to guide clinical practice regarding the judicious use and feasibility of different types of mind-body-based complementary and alternative medicine (CAM) for sleep problems in the elderly population.
- To perform cost benefit analysis of different mind-body CAMs after collecting qualitative data from participants.
- To examine the mediating roles of salivary cortisol and brain-derived neurotrophic factor (BDNF) as biological mechanisms underlying the potential beneficial effects of MBI and TCC on sleep quality, respectively.
- To examine the mediating roles of frontal midline theta and brain arousal level as neurological mechanisms underlying the anticipated beneficial effects of MBI and TCC on sleep quality, respectively.
- To enrich the etiological model of sleep disturbance through focusing on the effects of MBI and TCC on rumination and arousal level, respectively.
研究设计
- 研究类型
- Interventional
- 主要目的
- 随机平行对照
- 盲法
- None
入排标准
- 年龄范围
- 60 至 —（—）
- 性别
- All
入选标准
- •(1) aged 60 years or above;
- •(2) classified as experiencing sleep disturbances (poor sleep quality indicated by a score >5 on the PSQI (Tsai et al., 2005));
- •(3) primary education level or above and able to communicate in Cantonese;
- •(4) able to give informed consent;
- •(5) no previous experience with meditation or other mind-body techniques (e.g., Tai Chi or yoga).
排除标准
- •Elderly people with comorbid diagnoses of organic brain syndrome, substance misuse, psychosis, or intellectual disabilities will be excluded.
研究组 & 干预措施
Tai Chi Chuan (TCC) group
Tai Chi Chuan
Mindfulness-based intervention (MBI)
Mindfulness-based intervention (MBI)
Sleep hygiene education (SHE) control group
Sleep hygiene education
结局指标
主要结局
Subjective sleep quality
次要结局
- Objective sleep quality
- Subjective rumination
- Subjective hyperarousal
- Brain arousal level
- Frontal midline theta
研究者
研究点 (1)
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