Helium and organ protection during bypass surgery
- Conditions
- The aim of this clinical study is to investigate whether the non-anaesthetic noble gas helium induces preconditioning (PreC) and postconditioning (PostC) in patients undergoing coronary artery bypass graft (CABG) surgery.
- Registration Number
- NL-OMON25552
- Lead Sponsor
- Academic Medical Centre AmsterdamMeibergdreef 91100 DD Amsterdam
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 125
Inclusion Criteria
1. Age > 18 Years
2. Patients who have to undergo elective cardiac surgery (CABG without valve surgery)
Exclusion Criteria
1. Age < 18 years
2.Emergency operations
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main study parameters are detection of signalling pathway molecules involved in anaesthetic preconditioning (PKC-e, p38MAPK, ERK and HSP27). This will be done by molecular analysis of myocardial tissue samples in our laboratory.
- Secondary Outcome Measures
Name Time Method Secondary parameters are cardiac enzyme release after surgery (troponine T, CPK, CK-MB) and haemodynamics during surgery measured by transoesophageal echocardiography (TEE). Furthermore, several biomarkers will be investigated to see whether helium has a protective effect from surgery induced tissue on other organs; urine N-acetyl-glucosaminase (NAG) to estimate kidney damage, Intestinal-type fatty acid binding protein (I-FABP)/liver-type fatty acid binding protein (L-FABP)/ heart-type fatty acid binding protein (H-FABP) to estimate intestinal injury, and ¨¢-glutathione S-transferase (¨¢-GST) to estimate liver damage