Effect of aggressive nutrition strategies on neurodevelopment of preterm babies
Not Applicable
- Conditions
- Health Condition 1: null- Inborn Preterm neonates less than or equal to 32 weeks gestation and less than or equal to 1500 gm.Observational study.
- Registration Number
- CTRI/2017/09/009818
- Lead Sponsor
- il
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 260
Inclusion Criteria
All inborn preterm babies born at less than or equal to 32 weeks gestation AND less than equal to 1500 grams - enrollment on the first day of life itself
Exclusion Criteria
1.Babies <27 weeks gestation
2.Proven intra uterine infection
3.Major congenital malformations
4.HIV positive mothers
5.Need for extensive resuscitation at birth ( chest compression/medication)
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Difference in proportion of preterm very low birth weight (VLBW) babies with intact outcomes [survival without major Neurodevelopment Disability (NDD) and chronic lung disease of prematurity (CLD) at 12 months of age, corrected for prematurity] in babies managed in two time epochs, before (historical cohort); and after (study cohort) introduction of early aggressive nutrition strategies.Timepoint: 12 months of age, corrected for prematurity
- Secondary Outcome Measures
Name Time Method Difference in proportion of babies diagnosed to have NECTimepoint: During hospital stay;Difference in proportion of babies diagnosed to have ROP requiring laser therapyTimepoint: As per the ROP screening protocol;Difference in proportion of babies diagnosed to have sepsisTimepoint: During hospital stay;Difference in proportion of babies having Grade 3 or 4 IVH /PVL at term corrected age.Timepoint: Term corrected age