Restoration of Beta Cell Function and Cardiovascular Parameters in Relation to Adipoinsular and Enteroinsular Axes After Gastric Bypass Surgery in Severely Obese Patients With Type 2 Diabetes
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Diabetes Mellitus, Type 2
- Sponsor
- Cantonal Hospital of St. Gallen
- Enrollment
- 55
- Locations
- 2
- Primary Endpoint
- Acute insulin response (AIR) to glucose during IVGTT will be used as a primary variable characterizing the beta cell function
- Status
- Completed
- Last Updated
- 13 years ago
Overview
Brief Summary
Bariatric operations such as the gastric bypass procedure provide a unique in vivo model of improvement of pathological beta cell function. The presented double-centre study aims to comprehensively investigate different aspects of beta cell function in patients with type 2 diabetes (T2DM) with a wide range of disease duration after gastric bypass. In parallel, our project will address the aspects of changes in enteroinsular and adipoinsular axes as well as the early and late changes of other defined parameters after gastric bypass surgery.
Investigators
Bernd Schultes
Head of Interdisciplinary Obesity Center
Cantonal Hospital of St. Gallen
Eligibility Criteria
Inclusion Criteria
- •\> 18 years
- •indication forbariatric surgery or non-bariatric abdominal surgery
Exclusion Criteria
- •Pregnancy
Outcomes
Primary Outcomes
Acute insulin response (AIR) to glucose during IVGTT will be used as a primary variable characterizing the beta cell function
Time Frame: 10 days after gastric bypass
Secondary Outcomes
- OGTT calculations and modelling describing beta cell response to oral glucose load; Insulin and C-peptide areas under the curve (AUCs) during OGTT quantifying the incretin effect.(10 days after gastric bypass)
- • Plasma concentrations and adipose tissue expression of selected adipokines and inflammatory cytokines characterizing the adipoinsular axis(10 days after gastric bypass)