Low Dose of Midazolam is Superior to Conventional Dose for Rapid Sequence Intubation in Emergency Department (ED)

Not Applicable

Completed

• Conditions: Intubation
• Interventions: Drug: Low dose midazolam

• Registration Number: NCT00783731
• Lead Sponsor: Seoul National University Hospital

Brief Summary

Midazolam has been used in rapid sequence intubation for a long time, and the recommended dose is 0.1mg/kg. In some studies, however, the reduced dose has been used with the concern of hemodynamic instability. We would like to investigate that the low dose midazolam could be used rather than the standard recommended dose, and also compare it to the etomidate, recently used sedatives, with respect to the side effects and the easy performance of intubation.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-10
• Study First Submitted: 2008-10-30
• Study First Submitted QC: 2008-10-31
• Study First Posted: 2008-11-02
• Primary Completion: 2010-10
• Study Completion: 2011-01
• Status Verified: 2011-07
• Last Update Submitted: 2011-07-25
• Last Update Posted: 2011-07-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• patients who need rapid sequence intubation in emergency room

Exclusion Criteria

• in hypotension(systolic blood pressure less than 90 mmHg
• severe trauma patients
• pregnant
• allergic to midazolam, etomidate

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Low dose midazolam	Low dose midazolam	-

Trial Locations

Locations (2)

Seoul National University Bundang Hospital, Emergency room; 🇰🇷 Seongnam-si, Gyeonggi-do, Korea, Republic of

Boramae Medical Center; 🇰🇷 Seoul, Korea, Republic of