White Matter in Pediatric Bipolar Disorder: A DTI Study

Completed

• Conditions: Bipolar Disorder

• Registration Number: NCT00391235
• Lead Sponsor: Cambridge Health Alliance

Brief Summary

Fourteen subjects with bipolar disorder and 14 matching healthy controls, aged 6-13, will receive a magnetic resonance imaging (MRI) scan on a 3 Tesla scanner. They will also have a clinical interview, including the KSADS-PL. All subjects must be right-handed.

Detailed Description

We propose to investigate the connectivity of white matter tracts using diffusion tensor imaging (DTI) in children with very early onset bipolar disorder (BPD). We hypothesize that the connectivity between the prefrontal cortex and the temporal lobe and parietal lobe and limbic structures will be abnormal, indicating white matter and gray matter deficits in early onset BPD. We also hypothesize that the superior lateral fasciculus cingulum bundle and the inferior lateral fasciculus will have decreased fractional anisotropy in very early onset BPD relative to healthy controls.

Study Timeline

• Study Start: 2005-09
• Study First Submitted: 2006-10-19
• Study First Submitted QC: 2006-10-19
• Study First Posted: 2006-10-23
• Primary Completion: 2008-09
• Study Completion: 2008-10
• Status Verified: 2010-12
• Last Update Submitted: 2010-12-02
• Last Update Posted: 2010-12-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

• Age 6 to 13
• Male or female
• Right-handed

Exclusion Criteria

• IQ less than 70
• Learning disabilities
• History of autism, schizophrenia, anorexia or bulimia nervosa
• Substance abuse
• Claustrophobia
• Metal in body
• Pregnancy or lactation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Fractional anisotropy in brain white matter	Baseline

Trial Locations

Locations (1)

Cambridge Health Alliance; 🇺🇸 Medford, Massachusetts, United States