Assessing the impact of escalating fish oil consumption on n-3 polyunsaturated fatty acid (PUFA) content of transport, storage and functional pools

Not Applicable

Completed

• Conditions: Impact of fish-oil consumption on the fatty acid content of plasma; Nutritional, Metabolic, Endocrine; Fish oil consumption

• Registration Number: ISRCTN48398526
• Lead Sponsor: MRC Human Nutrition Research (UK)

Brief Summary

1. 2012 lipid pool results in: http://www.ncbi.nlm.nih.gov/pubmed/22932281 2. 2014 blood cell and plasma results in: http://www.ncbi.nlm.nih.gov/pubmed/24647395 3. 2014 results on effects of sex and age in https://www.ncbi.nlm.nih.gov/pubmed/24063767 4. 2015 results on use of plasma NEFA as a biomarker in https://www.ncbi.nlm.nih.gov/pubmed/26205910 5. 2015 results on differences in FA distribution between blood cells and plasma in https://www.ncbi.nlm.nih.gov/pubmed/26247960 6. 2017 lipidomics analysis results in https://www.ncbi.nlm.nih.gov/pubmed/28587463

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2006-04-28
• Study Completion: 2009-02-28
• Last Update Posted: 11 February 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 210

Inclusion Criteria

Men and women, aged 20-80 years with a body mass index (BMI) in the range 18-35 kg/m2 will be recruited to the study.

Exclusion Criteria

1. Known diagnosis of diabetes, cancer, cardiovascular disease or other chronic clinical conditions
2. Untreated hypertension
3. Concomitant prescription of anticoagulants, non-steroidal anti-inflammatory drugs (NSAIDS), aspirin, steroids or immunosuppressants
4. Following a special diet, including vegetarians
5. Allergies or intolerance to fish
6. Consumption of oily fish more than once a month
7. Smokers
8. History of substance abuse or alcoholism
9. Pregnant, <1 year post partum or currently planning pregnancy
10. Recent weight change (>2 kg in past 1 month)
11. Planning to change dietary habits, increase physical activity, change body weight, move away from the study centre locality or take a lengthy vacation during the time of the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified