Effect of Sleep Debt on Neurophysiological Responses to Heat Exposure

Recruiting

• Conditions: Sleep Disorder; Heat; Excess
• Interventions: Other: Sleep recording (at home); Other: Heat exposure; Other: Normal sleep; Other: Sleep restriction

• Registration Number: NCT05181345
• Lead Sponsor: Direction Centrale du Service de Santé des Armées

Brief Summary

Many people are required to work in stressful situations combining sleep debt and hot environmental conditions. If the effect of sleep debt on cognitive performance is proven, this effect could be increased, during heat exposure, through the deleterious effects of sleep debt on thermoregulatory abilities. These alterations may favour the occurrence of accidents.

The changes in cognitive performance induced by hyperthermia are also poorly characterised and often not dissociated from the effects of dehydration. Little is known about the effects of the combination of sleep debt and heat exposure on mental performance. Describing and understanding the alterations induced by this combined situation could provide a better understanding of the mechanisms explaining the deterioration of performance in hot conditions and promote the development of appropriate countermeasures.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-12-20
• Study First Submitted QC: 2021-12-20
• Study First Posted: 2022-01-06
• Study Start: 2022-01-14
• Status Verified: 2023-04
• Last Update Submitted: 2023-04-27
• Last Update Posted: 2023-04-28
• Primary Completion: 2024-02
• Study Completion: 2024-02

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• 18 to 35 years old
• Body Mass Index between 18 and 27 kg/m2
• Body weight ≥ 54 kg

Exclusion Criteria

• Presence or history of medical pathology (cardiological, renal, hepatic, cutaneous, intestinal, neurological...)
• Presence of a significant deviation from the normal values observed on the electrocardiogram
• History of heat stroke
• Known intolerance to heat (e.g. migraine sufferers)
• Presence of a contraindication to blood sampling, notably low venous capital, belonephobia
• Inability to ingest a capsule or refusal of the rectal probe
• Habitual consumption of caffeine > 500 mg per day
• Alcohol consumption greater than the equivalent of 3 glasses of wine per week
• Consumption of narcotics
• Smoking > 0.5 packet of cigarettes per day
• Undergoing habitual medication
• Pregnant or breastfeeding woman

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Reduced sleep first	Sleep restriction	The night before the first heat exposure, the participants sleep will be restricted to 3 hours in bed. The night before the second heat exposure, the participants will have a normal night at home.
Normal sleep first	Sleep recording (at home)	The night before the first heat exposure, the participants will have a normal night at home. The night before the second heat exposure, the participants sleep will be restricted to 3 hours in bed.
Normal sleep first	Sleep restriction	The night before the first heat exposure, the participants will have a normal night at home. The night before the second heat exposure, the participants sleep will be restricted to 3 hours in bed.
Reduced sleep first	Sleep recording (at home)	The night before the first heat exposure, the participants sleep will be restricted to 3 hours in bed. The night before the second heat exposure, the participants will have a normal night at home.
Normal sleep first	Normal sleep	The night before the first heat exposure, the participants will have a normal night at home. The night before the second heat exposure, the participants sleep will be restricted to 3 hours in bed.
Reduced sleep first	Heat exposure	The night before the first heat exposure, the participants sleep will be restricted to 3 hours in bed. The night before the second heat exposure, the participants will have a normal night at home.
Reduced sleep first	Normal sleep	The night before the first heat exposure, the participants sleep will be restricted to 3 hours in bed. The night before the second heat exposure, the participants will have a normal night at home.
Normal sleep first	Heat exposure	The night before the first heat exposure, the participants will have a normal night at home. The night before the second heat exposure, the participants sleep will be restricted to 3 hours in bed.

Primary Outcome Measures

Name	Time	Method
Number of errors at the Stroop test	Through study completion (25 months)	Written color names that differ from the color ink they are printed on will be displayed on a computer screen. In the first trial, the participant must say the written word. In the second trial, the participant must name the ink color instead. The higher the number of correct answers, the higher the score.

Trial Locations

Locations (1)

Institut de Recherche Biomédicale des Armées; 🇫🇷 Brétigny-sur-Orge, France