Chronic Sleep Deprivation and Changes in Cortical and Hippocampal Volume
- Conditions
- Cortical IrregularitySleep DeprivationHippocampal Atrophy
- Interventions
- Diagnostic Test: Cerebral Nuclear Magnetic Resonance
- Registration Number
- NCT06260280
- Lead Sponsor
- Instituto Mexicano del Seguro Social
- Brief Summary
Sleep is a physiological state that is essential for human performance, including academic, occupational, interpersonal, and psychological aspects. Sleep disruption or deprivation leads to a loss of psychomotor skills and an increased association with various diseases. Therefore, it is critical to assess how chronic sleep deprivation affects medical residents who work long shifts, including those assigned during their training.
- Detailed Description
Objective: To determine if there is an association between chronic sleep deprivation and changes in cortical and hippocampal volume, assessed by nuclear magnetic resonance, in first-year medical residents assigned to the High Specialty Medical Unit, Specialty Hospital No. 1, National Medical Center of Bajío, during a period of 2 months after their admission.
Materials and Methods: This is a retrospective cohort study of first-year residents at UMAE T1, with a calculated sample size of 37 patients. Results are presented using descriptive statistics with mean and standard deviation or median with confidence intervals, depending on the type of variable. The relationship between MRI values and sleep deprivation will be assessed using Pearson's correlation coefficient or its non-parametric equivalent.
Ethical considerations: The study will be conducted with the informed consent of the patients in accordance with the General Health Law on Research and the Helsinki Declaration of 1975. The risk associated with this study is more than minimal.
Resources: Magnetic resonance studies will be performed at the High Specialty Medical Unit, Specialty Hospital No. 1, National Medical Center of Bajio, under the supervision of affiliated physicians specializing in the field of radiology and a fourth year resident in Diagnostic and Therapeutic Imaging.
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 37
- New resident physicians assigned to the High Specialty Medical Unit, Hospital de Especialidades No. 1 Centro Médico Nacional Del Bajío.
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- Patients who have ingested caffeine, nicotine or alcohol in the last 24 hours.
- Patients with sleep disorders who present a score greater than 5 in the initial assessment of the Pittsburgh Sleep Quality Index.
- Patients with psychiatric treatment.
- Patients ingesting medications that intervene in the awake state.
- Patients with drug abuse (marijuana, cocaine, etc.).
- Patients with claustrophobia.
- Patients with metallic implants.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description First-year medical residents Cerebral Nuclear Magnetic Resonance All first-year residents entering our department for any of the different specialties will undergo a nuclear magnetic resonance scan before starting their shifts and a control scan 2 months into their residency to evaluate if there is an association between chronic sleep deprivation and changes in cortical and hippocampal volume.
- Primary Outcome Measures
Name Time Method Change in Hippocampal volumetry. 2 months The hippocampal volume is obtained using the three planes of visualization of T1-weighted images in volumetric sequences. Volumetric analysis will be performed using volBrain and will be reported in cm3.
Change in cortical volumetry 2 months The cortical volume is obtained using the three planes of visualization of T1-weighted images in volumetric sequences. Volumetric analysis will be performed using volBrain and will be reported in cm3.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Unidad Medica de Alta Especialidad No. 1, Bajío
🇲🇽Leon, Guanajuato, Mexico