Sleep Deprivation and Advancement of Sleep Period as Treatment for Bipolar Depression.

Not Applicable

Terminated

• Conditions: Bipolar Disorder
• Interventions: Behavioral: Sleep deprivation and sleep phase advancement; Other: usual treatment

• Registration Number: NCT00229151
• Lead Sponsor: Norwegian University of Science and Technology

Brief Summary

The purpose of this study is to determine if sleep deprivation and sleep phase advancement is effective treatment of bipolar patients in a depressive phase.

Detailed Description

Background: The onset of therapeutic action for most anti-depressive treatments is usually two weeks. During this period patients suffer from great symptomatic distress. Treatment options that are effective in this period is therefore of interest for psychiatric wards.

Aim: To explore if sleep deprivation and three days sleep phase advancement is effective treatment for inpatients with bipolar disorder in a depressive phase.

Method: A randomized controlled trial with 24 patients diagnosed with bipolar disorder. Patients will be randomized to treatment as usual in an psychiatric ward, or sleep deprivation and three days sleep phase advancement. Patients in the treatment as usual group will be offered treatment with sleep deprivation and sleep phase advancement after five weeks if they still meet inclusion criteria.

Study Timeline

• Study First Submitted: 2005-09-27
• Study First Submitted QC: 2005-09-28
• Study First Posted: 2005-09-29
• Study Start: 2005-10
• Primary Completion: 2011-12
• Study Completion: 2011-12
• Status Verified: 2012-04
• Last Update Submitted: 2012-04-06
• Last Update Posted: 2012-04-09

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 5

Inclusion Criteria

• Bipolar disorder, depressive phase

Exclusion Criteria

• substance abuse, psychotic symptoms, suicidal intentions, active mania/hypomania.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Sleep deprivation	Sleep deprivation and sleep phase advancement	Sleep deprivation and sleep phase advancement
usual treatment	usual treatment	-

Primary Outcome Measures

Name	Time	Method
Scores on rating scales for depression and symptom severity.	one month

Secondary Outcome Measures

Name	Time	Method
Scores on rating scales for anxiety, mania, cognitive processing, and sleep quality.	one month

Trial Locations

Locations (1)

Norwegian University of Science and Technology, Institute of Neuroscience; 🇳🇴 Trondheim, Norway