To Determine if Sleep Deprivation Results in Increased Esophageal Acid Exposure
Completed
- Conditions
- Gastroesophageal Disease
- Registration Number
- NCT01093339
- Lead Sponsor
- Southern Arizona VA Health Care System
- Brief Summary
The purpose of this study is to determine if sleep deprivation results in increased esophageal acid exposure in healthy controls and gastroesophageal reflux disease (GERD) patients.
- Detailed Description
To determine if increased esophageal acid exposure is mediated by altering appetite regulation. To assess if there is any relationship between sleep deprivation and the serum level of TNF-alfa (a protein that can be elevated in inflammation).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
- Male/Female - 18-80
- 2 or more episodes of heartburn a week for last 3 months
Exclusion Criteria
- Previous upper GI surgery
- Underlying co-morbidity
- Narcotic medications
- Psychotropic's and Benzodiazapines medications
- Hx of psychological abnormalities
- Hx of ETOH in previous 6 mos.
- Diabetes Mellitus
- Neuropathy
- Seizures
- Sleep Apnea
- Co-morbidity that interfere w/sleep
- Women who are pregnant, or childbearing yrs, not on BC
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
SArizonaVAHCS
🇺🇸Tucson, Arizona, United States