The Stockholm Sleepy Brain Study: Effects of Sleep Deprivation on Cognitive and Emotional Processing in Young and Old

Not Applicable

Completed

• Conditions: Sleep Deprivation
• Interventions: Behavioral: Full sleep; Behavioral: Partial sleep deprivation allowing 3 h sleep at night

• Registration Number: NCT02000076
• Lead Sponsor: Mats Lekander

Brief Summary

The main purpose of this study is to investigate the effects of partial sleep deprivation (PSD) on resting state brain connectivity, emotional contagion, empathy, and emotional regulation.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-11
• Study First Submitted: 2013-08-13
• Study First Submitted QC: 2013-11-26
• Study First Posted: 2013-12-03
• Primary Completion: 2014-03
• Study Completion: 2014-05
• Status Verified: 2016-05
• Last Update Submitted: 2016-05-13
• Last Update Posted: 2016-05-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 98

Inclusion Criteria

• 20-30 years of age, inclusive OR 65-75 years of age, inclusive

• Able to understand spoken and written Swedish (in order to understand instructions)

• Normal or corrected-to-normal vision not using glasses

• Not colour blind

• Right-handed

• Free from ferromagnetic objects in body

• No history of any neurologic or psychiatric illness including drug abuse

• No history of diabetes nor hypertension

  • No depression according to ratings using the Hospital Anxiety and Depression scale (HAD)
  • No insomnia according to ratings using the Insomnia Severity Index (ISI) and Karolinska Sleep Questionnaire (KSQ)

• No use of psychotropic drugs

• Not studying or working in medicine, psychology, nor behavioural science

• Not suffering from severe seasonal allergy

• No use of cortisone, anti-histamines, nor any other immune-modulating drugs

• Habitual intake of no more than 4 cups of coffee per day or the equivalent in terms of caffeine

• No daily use of nicotine

Exclusion Criteria

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Full sleep	Full sleep	Sleep with no restriction
Sleep deprivation	Partial sleep deprivation allowing 3 h sleep at night	Partial sleep deprivation allowing 3 h sleep at night

Primary Outcome Measures

Name	Time	Method
Blood oxygen level-dependent response in amygdala to angry faces (t/z-score from statistical parametric mapping)	Change between 1st and 2nd MRI scanning session (approx. 1 month later)	This registration is made in order to pre-specify hypotheses in a basic science project. For a full list of outcomes and hypotheses, see study description (above).

Trial Locations

Locations (1)

Karolinska Institutet, Karolinska Universitetssjukhuset i Solna; 🇸🇪 Stockholm, None/Not Applicable, Sweden