Predictive factors associated with in-hospital mortality in acute myeloid leukemia patients after induction chemotherapy
Completed
- Conditions
- Acute myeloid leukemia patients admitted for induction chemotherapy treatment.acute myeloid leukemia, predictor, mortality, chemotherapy
- Registration Number
- TCTR20240810001
- Lead Sponsor
- /A
- Brief Summary
19 patients (21%) died during the hospitalization within 30 days after chemotherapy. The leading cause of death (89%) was febrile neutropenia. According to multivariate analysis, lung infection (HR3.6, p 0.027) and fever before hemotherapy (HR3.5, p 0.049) were predictive factors associated with in-hospital death. A 30-day survival rate was 78.4%.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 90
Inclusion Criteria
Adult AML patient, newly diagnosis
age > 15 y
plan high intensive chemotherapy
Exclusion Criteria
death before start chemotherapy
change plan to palliative or low dose treatment
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method death 30 day death after chemotherapy at 30 day,predictive factors associated with death 30 days 30 day mortality
- Secondary Outcome Measures
Name Time Method induction death rate 30 day death/survive at 30 days after chemotherapy,survival rate 30 day patient who survive at 30 day after chemotherapy,complete remission rate after discharge from induction chemotherapy session number of patients with complete remission evaluate after complete treatment