Multicenter study of transcranial doppler in acute hepatic failure patients to predict encephalopathy onset
Not Applicable
- Conditions
- Health Condition 1: K720- Acute and subacute hepatic failureHealth Condition 2: T604- Toxic effect of rodenticides
- Registration Number
- CTRI/2021/02/031428
- Lead Sponsor
- Amrita institute of medical sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients having acute liver failure
Exclusion Criteria
Age less than 18
Hemodynamics instability
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate the sensitivity of resistive index to predict onset of severe encephalopathy ( grade 3 or intubation ) by 48 hours in.adult acute liver failure patientsTimepoint: Daily , for 7 days
- Secondary Outcome Measures
Name Time Method To evaluate the sensitivity of Resistive Index (RI) to predict onset of severe encephalopathy (Grade 3 or above, or intubation) by 72 hours in adult Acute Liver Failure (ALF) patientsTimepoint: 72 hours;. To evaluate the sensitivity of Pulsatility Index (PI) to predict onset of severe encephalopathy (Grade 3 or above, or intubation) by 72 hours in adult Acute Liver Failure (ALF) patients.Timepoint: 72 hours;To evaluate other indices like Pulsatility Index (PI) to predict onset of severe encephalopathy (Grade 3 or above, or intubation) by 48 hours in adult Acute Liver Failure (ALF) patients. <br/ ><br>Timepoint: 48 hours;To evaluate the correlation of arterial ammonia with degree of encephalopathyTimepoint: 72 hours;To evaluate the correlation of the RI, PI and arterial ammonia to grade of encephalopathy as the patient recovers, in those who recover either spontaneously or after liver transplantationTimepoint: NA