Evaluation of Remote Preconditioning on Heart Resistance to Ischemia and Reperfusion Injury

University of Campinas, Brazil1 site in 1 country120 target enrollmentAugust 2013

ConditionsCoronary Artery Disease Valvular Heart Disease

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Coronary Artery Disease
Sponsor: University of Campinas, Brazil
Enrollment: 120
Locations: 1
Primary Endpoint: Molecular pathway activation
Last Updated: 12 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Strategies for myocardial protection during open heart surgeries are desired. Several experimental studies have shown beneficial effects of remote ischemic preconditioning (RIPC). The underlying mechanisms are not totally understood. This study intends to evaluate molecular mechanisms involved with RIPC on myocardium of patients underwent open heart surgeries.

Registry

clinicaltrials.gov

Start Date

August 2013

End Date

August 2015

Last Updated

12 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

University of Campinas, Brazil

Responsible Party

Principal Investigator

Orlando Petrucci

Phd

University of Campinas, Brazil

Eligibility Criteria

Inclusion Criteria

•Patients older than 18 years
•Scheduled for coronary artery bypass grafting with or without valve replacement associated
•Use of blood cardioplegia
•EuroSCORE II greater than or equal to 1.0%

Exclusion Criteria

•History of cardiogenic shock
•Complications in the admission
•Pregnant patients
•Severe peripheral arterial disease affecting the upper limbs
•Liver failure (bilirubin ˃ 20 mmol / L, INR 2.0 ˃)
•Significant pulmonary disease (˂ FEV1 40%)
•Renal failure with glomerular filtration rate ˂ ml/min/1,73 m²
•Concomitant treatment with glibenclamide or nicorandil (medications that interfere with cardioprotection induced by IPCR)