Application of Remote Ischemic Preconditioning in Patients Undergoing Open Heart Surgeries
Not Applicable
- Conditions
- Coronary Artery DiseaseValvular Heart Disease
- Registration Number
- NCT01906918
- Lead Sponsor
- University of Campinas, Brazil
- Brief Summary
Strategies for myocardial protection during open heart surgeries are desired. Several experimental studies have shown beneficial effects of remote ischemic preconditioning (RIPC). The underlying mechanisms are not totally understood. This study intends to evaluate molecular mechanisms involved with RIPC on myocardium of patients underwent open heart surgeries.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
- Patients older than 18 years
- Scheduled for coronary artery bypass grafting with or without valve replacement associated
- Use of blood cardioplegia
- EuroSCORE II greater than or equal to 1.0%
Exclusion Criteria
- History of cardiogenic shock
- Complications in the admission
- Pregnant patients
- Severe peripheral arterial disease affecting the upper limbs
- Liver failure (bilirubin ˃ 20 mmol / L, INR 2.0 ˃)
- Significant pulmonary disease (˂ FEV1 40%)
- Renal failure with glomerular filtration rate ˂ ml/min/1,73 m²
- Concomitant treatment with glibenclamide or nicorandil (medications that interfere with cardioprotection induced by IPCR)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Inflammatory response 10 days Molecular pathway activation 2 days
- Secondary Outcome Measures
Name Time Method All cause of mortality 180 days
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular pathways does remote ischemic preconditioning modulate in myocardial protection during open heart surgery?
How does remote ischemic preconditioning compare to traditional cardioplegic solutions in reducing ischemia-reperfusion injury in coronary artery disease patients?
Which biomarkers are associated with enhanced response to remote ischemic preconditioning in valvular heart disease patients undergoing surgery?
What are the potential adverse events linked to remote ischemic preconditioning in cardiac surgical procedures and how are they managed?
Are there combination therapies involving remote ischemic preconditioning that improve outcomes in patients with complex coronary artery disease or valvular heart disease?
Trial Locations
- Locations (1)
Hospital das Clínicas da Unicamp
🇧🇷Campinas, Sao Paulo, Brazil
Hospital das Clínicas da Unicamp🇧🇷Campinas, Sao Paulo, BrazilFany LimaContact++55 (19) 3521-7131fanyslima@gmail.comOrlando Petrucci, MD, PhDPrincipal InvestigatorFany Lima, RNSub InvestigatorPedro Paulo M Oliveira, MD, PhDSub InvestigatorLindemberg M Silveira-Filho, MD, PhDSub InvestigatorKarlos AS Vilarinho, MD, PhDSub InvestigatorElaine S Severino, MD, PhDSub InvestigatorDaniela D Carvalho, PhDSub Investigator