Influence of BCG vaccine as a booster for TDaP-IPV vaccinatio

Recruiting

• Conditions: Pertussis; Whooping cough; 10027665; 10002252

• Registration Number: NL-OMON40745
• Lead Sponsor: Radboudumc

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 51

Inclusion Criteria

Healthy adults

Exclusion Criteria

Systemic medication other oral contraceptives. Diseases resulting in immunodeficiency. Previous BCG vaccination. Pregnancy.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Comparison of pertussis-specific antibody and T-cell responses, as well as gene<br /><br>transcription between BCG, TDaP-IPV and BCG+TDaP-IPV vaccinated groups.<br /><br>Comparison of cytokine responses to unrelated antigens and/or pathogens before<br /><br>and after BCG, TDaP-IPV or BCG+TDaP-IPV vaccination.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Epigenetic markers associated with immune function.</p><br>