Immunological effects of BCG on vaccination with the yellow fever vaccine.

Completed

• Conditions: Immune modulation; modulation of the immune system; 10002252

• Registration Number: NL-OMON40902
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2016-02-08
• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

Healthy
18-55 years old

Exclusion Criteria

Exposed to TBC, BCG or yellow fever (vaccine), use of mediation

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>According to the objectives:<br /><br>1) Increase of in vitro cytokine production of PBMCs after stimulation with<br /><br>different pathogens compared to before yellow fever vaccination. (only placebo<br /><br>group)<br /><br>2) Yellow fever antibody titers, Th-immune responses, and proinflammatory<br /><br>cytokine production in BCG versus placebo vaccinated volunteers.<br /><br>3) The rate of clearance of the circulating yellow fever vaccine virus in BCG-<br /><br>versus placebo-vaccinated volunteers.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>n.v.t.</p><br>