The physiological effects of high dose zopiclone in people with obstructive sleep apnoea

Phase 2

Completed

• Conditions: Obstructive Sleep Apnoea; Respiratory - Sleep apnoea

• Registration Number: ACTRN12617000988358
• Lead Sponsor: euroscience Research Australia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-07-10
• Study Completion: 2018-11-06
• Last Update Posted: 15 July 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Otherwise healthy, men and women with obstructive sleep apnoea

Patients who have a low respiratory arousal threshold (between zero and -15cmH2O epiglottic pressure just prior to arousal) as estimated from their baseline sleep study.

Exclusion Criteria

Patients with confirmed overnight blood oxygen saturation nadir (SaO2) less than 70% from baseline sleep study
Patients with a high arousal threshold (less than -25cmH2O epiglottic pressure prior to arousal)

Patients taking medications known to affect sleep or muscle activity

Women lactating, pregnant or of childbearing potential who are not willing to avoid becoming pregnant during the study

Patients with any other medical condition which may interfere in the evaluation of the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified